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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:Rleg2_3953
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000959351 – 222N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST222

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_3953

Structurei

3D structure databases

ProteinModelPortaliB5ZV69
SMRiB5ZV69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

B5ZV69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPDIKICGL KTPEAIDRAL ERGATHIGFI FFEKSPRYIE PDLAGKLAEP
60 70 80 90 100
ARGKAKIVAV VVDPSNDELD EIVSLLKPDI LQLHGNESPE HVLTIKALYG
110 120 130 140 150
LPVMKVFSVR TADDLKRVEA YIGIADRFLF DAKAPKGSEL PGGNGISFDW
160 170 180 190 200
SLLSWLDGSI DYMLSGGLNK DNVADALVKT KARGIDVSSG VETAPGVKSV
210 220
AMIDEFFDAV EEADAPVMAS GS
Length:222
Mass (Da):23,856
Last modified:November 25, 2008 - v1
Checksum:iAD812850CBB0C563
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA Translation: ACI57215.1
RefSeqiWP_012559404.1, NC_011369.1

Genome annotation databases

EnsemblBacteriaiACI57215; ACI57215; Rleg2_3953
GeneIDi34192906
KEGGirlt:Rleg2_3953

Similar proteinsi

Entry informationi

Entry nameiTRPF_RHILW
AccessioniPrimary (citable) accession number: B5ZV69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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