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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei635ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Rleg2_3924
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913511 – 876Leucine--tRNA ligaseAdd BLAST876

Proteomic databases

PRIDEiB5ZV40

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_3924

Structurei

3D structure databases

ProteinModelPortaliB5ZV40
SMRiB5ZV40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi632 – 636"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B5ZV40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATERYNPRD AEPRWQQKWN EDKVFETDNS DPREKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYAMG DVVARYKRAR GYNVLHPMGW DAFGMPAENA AMERGVHPAS
110 120 130 140 150
WTYQNIGSMK AQLKAMGLSL DWSREFATCD VEYYQHQQHL FLDFLEKGLV
160 170 180 190 200
YRKQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFKITDFS
210 220 230 240 250
QDLLDALDTL DQWPEKVRLM QKNWIGRSEG LTIRWEIVAE TAPAGETEIT
260 270 280 290 300
VYTTRPDTLF GASFLAIAAD HPLAKDAAAK NADIEAFCEE CRRAGTSLAA
310 320 330 340 350
LETAEKKGMD TGIRVRHPLD PSWELPVYVA NFVLMDYGTG AIFGCPSGDQ
360 370 380 390 400
RDLDFARKYG LPVVAVVMPQ DGDAASFSVG DTAYDGDGVM INSRFLDGKT
410 420 430 440 450
TEEAFNIVAD RLSAASLGNT PQGERKVNFR LRDWGISRQR YWGCPIPVIH
460 470 480 490 500
CDDCGVVPVP KKDLPVKLPD DVTFDQPGNP LDRHPTWRHV SCPTCGKDAR
510 520 530 540 550
RETDTMDTFV DSSWYFTRFT APWEAKPTDP EAANRWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMRETGHVA ATEPFKGLFT QGMVVHETYS RGAGGSREWV
610 620 630 640 650
APADIRIEEI DGKRRALLLT TGEEIAIGSI EKMSKSKKNV VDPDDIIASY
660 670 680 690 700
GADTARFFVL SDSPPERDVI WSEAGVEGAH RFTQRLWRLI SEAADALSAV
710 720 730 740 750
APAPATEGEA LSISQAAHRT LKAVENDYDK LWFNKAVARI YELVNALAAP
760 770 780 790 800
MTRVAAGEGD ATYRAAVRNA AEILIQLVAP MTPHLAEECW MALGNEGLLA
810 820 830 840 850
RTGWPQYGET LVIENDVVLP VQINGKKRAE LTISRDADQN AVTNAVLDLD
860 870
AVKNALNGQA PKKIIVVPQR IVNIVV
Length:876
Mass (Da):97,894
Last modified:November 25, 2008 - v1
Checksum:i936E5BB1414FE104
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA Translation: ACI57186.1
RefSeqiWP_012559382.1, NC_011369.1

Genome annotation databases

EnsemblBacteriaiACI57186; ACI57186; Rleg2_3924
GeneIDi34193691
KEGGirlt:Rleg2_3924

Similar proteinsi

Entry informationi

Entry nameiSYL_RHILW
AccessioniPrimary (citable) accession number: B5ZV40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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