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B5ZV40

- SYL_RHILW

UniProt

B5ZV40 - SYL_RHILW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei635 – 6351ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRLEG395492:GJB3-3980-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Rleg2_3924
    OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
    Taxonomic identifieri395492 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008330: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Leucine--tRNA ligasePRO_1000091351Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395492.Rleg2_3924.

    Structurei

    3D structure databases

    ProteinModelPortaliB5ZV40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi632 – 6365"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5ZV40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATERYNPRD AEPRWQQKWN EDKVFETDNS DPREKYYVLE MFPYPSGRIH    50
    MGHVRNYAMG DVVARYKRAR GYNVLHPMGW DAFGMPAENA AMERGVHPAS 100
    WTYQNIGSMK AQLKAMGLSL DWSREFATCD VEYYQHQQHL FLDFLEKGLV 150
    YRKQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFKITDFS 200
    QDLLDALDTL DQWPEKVRLM QKNWIGRSEG LTIRWEIVAE TAPAGETEIT 250
    VYTTRPDTLF GASFLAIAAD HPLAKDAAAK NADIEAFCEE CRRAGTSLAA 300
    LETAEKKGMD TGIRVRHPLD PSWELPVYVA NFVLMDYGTG AIFGCPSGDQ 350
    RDLDFARKYG LPVVAVVMPQ DGDAASFSVG DTAYDGDGVM INSRFLDGKT 400
    TEEAFNIVAD RLSAASLGNT PQGERKVNFR LRDWGISRQR YWGCPIPVIH 450
    CDDCGVVPVP KKDLPVKLPD DVTFDQPGNP LDRHPTWRHV SCPTCGKDAR 500
    RETDTMDTFV DSSWYFTRFT APWEAKPTDP EAANRWLPVD QYIGGIEHAI 550
    LHLLYSRFFT RAMRETGHVA ATEPFKGLFT QGMVVHETYS RGAGGSREWV 600
    APADIRIEEI DGKRRALLLT TGEEIAIGSI EKMSKSKKNV VDPDDIIASY 650
    GADTARFFVL SDSPPERDVI WSEAGVEGAH RFTQRLWRLI SEAADALSAV 700
    APAPATEGEA LSISQAAHRT LKAVENDYDK LWFNKAVARI YELVNALAAP 750
    MTRVAAGEGD ATYRAAVRNA AEILIQLVAP MTPHLAEECW MALGNEGLLA 800
    RTGWPQYGET LVIENDVVLP VQINGKKRAE LTISRDADQN AVTNAVLDLD 850
    AVKNALNGQA PKKIIVVPQR IVNIVV 876
    Length:876
    Mass (Da):97,894
    Last modified:November 25, 2008 - v1
    Checksum:i936E5BB1414FE104
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001191 Genomic DNA. Translation: ACI57186.1.
    RefSeqiYP_002283412.1. NC_011369.1.

    Genome annotation databases

    EnsemblBacteriaiACI57186; ACI57186; Rleg2_3924.
    GeneIDi6982688.
    KEGGirlt:Rleg2_3924.
    PATRICi23132136. VBIRhiLeg95088_5867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001191 Genomic DNA. Translation: ACI57186.1 .
    RefSeqi YP_002283412.1. NC_011369.1.

    3D structure databases

    ProteinModelPortali B5ZV40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395492.Rleg2_3924.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI57186 ; ACI57186 ; Rleg2_3924 .
    GeneIDi 6982688.
    KEGGi rlt:Rleg2_3924.
    PATRICi 23132136. VBIRhiLeg95088_5867.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RLEG395492:GJB3-3980-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
      , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM2304.

    Entry informationi

    Entry nameiSYL_RHILW
    AccessioniPrimary (citable) accession number: B5ZV40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3