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B5ZUG3

- BETB_RHILW

UniProt

B5ZUG3 - BETB_RHILW

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene
betB, Rleg2_0777
Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Potassium 1 By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi244 – 2441Potassium 2; via carbonyl oxygen By similarity
Active sitei250 – 2501Proton acceptor By similarity
Binding sitei284 – 2841NAD/NADP By similarity
Binding sitei384 – 3841NAD/NADP By similarity
Metal bindingi454 – 4541Potassium 2; via carbonyl oxygen By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Active sitei461 – 4611Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi228 – 2336NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciRLEG395492:GJB3-786-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Rleg2_0777
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008330: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotationPRO_1000133958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi395492.Rleg2_0777.

Structurei

3D structure databases

ProteinModelPortaliB5ZUG3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCTDEMTI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZUG3-1 [UniParc]FASTAAdd to Basket

« Hide

MKAQPKASHF IDGEYVEDTD GTVIESLYPA TGEVIARLHA ATPAIVEKAI    50
AAARRAQPEW AAMSPMARGR ILKRAADIMR ERNRALSELE TLDTGKPIQE 100
TIVADPTSGA DAFEFFGGVA PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG 150
AWNYPQQIAC WKAAPALISG NAMVFKPSEN TPLGALKIAE ILHEAGLPKG 200
LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA AGNLKHVTME 250
LGGKSPLIVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKGIKTEF 300
LKRLKARTEA MLIGDPLDEA TQIGPMVSWA QREKVVAYIE KGKAEGATLV 350
AGGGIPNNVS GEGYYIQPTV FADVTDDMTI AREEIFGPVM SVLDFDDEDE 400
VIARANASEF GLSGGVFTAD LSRAHRVVDR LEAGTLWINA YNLAPVEIPF 450
GGSKQSGFGR ENSLAALEHY SELKTVYVGM GPVQAPY 487
Length:487
Mass (Da):51,740
Last modified:November 25, 2008 - v1
Checksum:i588CC5EC6CBF279F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001191 Genomic DNA. Translation: ACI54072.1.
RefSeqiYP_002280298.1. NC_011369.1.

Genome annotation databases

EnsemblBacteriaiACI54072; ACI54072; Rleg2_0777.
GeneIDi6979495.
KEGGirlt:Rleg2_0777.
PATRICi23125440. VBIRhiLeg95088_2563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001191 Genomic DNA. Translation: ACI54072.1 .
RefSeqi YP_002280298.1. NC_011369.1.

3D structure databases

ProteinModelPortali B5ZUG3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395492.Rleg2_0777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI54072 ; ACI54072 ; Rleg2_0777 .
GeneIDi 6979495.
KEGGi rlt:Rleg2_0777.
PATRICi 23125440. VBIRhiLeg95088_2563.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CTDEMTI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci RLEG395492:GJB3-786-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
    , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM2304.

Entry informationi

Entry nameiBETB_RHILW
AccessioniPrimary (citable) accession number: B5ZUG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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