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B5ZUG2

- BETA_RHILW

UniProt

B5ZUG2 - BETA_RHILW

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciRLEG395492:GJB3-785-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Rleg2_0776
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008330: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000133337Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_0776.

Structurei

3D structure databases

ProteinModelPortaliB5ZUG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZUG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQADFVIIGS GSAGSALAYR LSEDGKNSVL VIEAGGSDFG PFIQMPAALA
60 70 80 90 100
WPMSMKRYNW GYLSEPEPNL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE
110 120 130 140 150
DFNRWEELGA GGWAYADVLP YFKRMEHSHG GEEGWRGTDG PLHVQRGGFT
160 170 180 190 200
NPLFRAFVEA GKQAGFETTE DYNGSKQEGF GLMEQTIFSG RRWSAANAYL
210 220 230 240 250
KPALKRKNVE IIYGFAQRIV IEDGRATGVE IERGGKIEVV KANREVIVSA
260 270 280 290 300
SSFNSPKLLM LSGIGPGEHL KEMGIEVKAD RPGVGANLQD HMEFYFQQVS
310 320 330 340 350
TKPVSLYSWL PWFWQGVAGA QWLLSKGGLG ASNQFEACAF LRSAPGLKQP
360 370 380 390 400
DIQYHFLPVA ISYDGKAAAK SHGFQVHVGY NLSKSRGSVT LRSPDPKADP
410 420 430 440 450
VLRFNYMSHA EDWEKFRHCV RLTRELFGQA AFDDYRGAEI QPGESVQSDE
460 470 480 490 500
EIDAFLREHL ESAYHPCGTC KMGAKDDPMA VVDPQTRVIG VEALRVADSS
510 520 530 540
IFPHVTYGNL NGPSIMTGEK AADHILGKQP LARSNQEPWV NPRAAVSDR
Length:549
Mass (Da):60,411
Last modified:November 25, 2008 - v1
Checksum:iE3D1869F1DE37DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI54071.1.
RefSeqiWP_012556953.1. NC_011369.1.
YP_002280297.1. NC_011369.1.

Genome annotation databases

EnsemblBacteriaiACI54071; ACI54071; Rleg2_0776.
GeneIDi6979494.
KEGGirlt:Rleg2_0776.
PATRICi23125438. VBIRhiLeg95088_2562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI54071.1 .
RefSeqi WP_012556953.1. NC_011369.1.
YP_002280297.1. NC_011369.1.

3D structure databases

ProteinModelPortali B5ZUG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395492.Rleg2_0776.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI54071 ; ACI54071 ; Rleg2_0776 .
GeneIDi 6979494.
KEGGi rlt:Rleg2_0776.
PATRICi 23125438. VBIRhiLeg95088_2562.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci RLEG395492:GJB3-785-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
    , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM2304.

Entry informationi

Entry nameiBETA_RHILW
AccessioniPrimary (citable) accession number: B5ZUG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3