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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei465Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 33FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Rleg2_0776
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001333371 – 549Oxygen-dependent choline dehydrogenaseAdd BLAST549

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_0776.

Structurei

3D structure databases

ProteinModelPortaliB5ZUG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6. Bacteria.
COG2303. LUCA.
HOGENOMiHOG000139600.
KOiK00108.
OMAiWPEYDFI.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00750. Choline_dehydrogen. 1 hit.
InterProiIPR011533. BetA.
IPR023753. FAD/NAD-binding_dom.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZUG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQADFVIIGS GSAGSALAYR LSEDGKNSVL VIEAGGSDFG PFIQMPAALA
60 70 80 90 100
WPMSMKRYNW GYLSEPEPNL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE
110 120 130 140 150
DFNRWEELGA GGWAYADVLP YFKRMEHSHG GEEGWRGTDG PLHVQRGGFT
160 170 180 190 200
NPLFRAFVEA GKQAGFETTE DYNGSKQEGF GLMEQTIFSG RRWSAANAYL
210 220 230 240 250
KPALKRKNVE IIYGFAQRIV IEDGRATGVE IERGGKIEVV KANREVIVSA
260 270 280 290 300
SSFNSPKLLM LSGIGPGEHL KEMGIEVKAD RPGVGANLQD HMEFYFQQVS
310 320 330 340 350
TKPVSLYSWL PWFWQGVAGA QWLLSKGGLG ASNQFEACAF LRSAPGLKQP
360 370 380 390 400
DIQYHFLPVA ISYDGKAAAK SHGFQVHVGY NLSKSRGSVT LRSPDPKADP
410 420 430 440 450
VLRFNYMSHA EDWEKFRHCV RLTRELFGQA AFDDYRGAEI QPGESVQSDE
460 470 480 490 500
EIDAFLREHL ESAYHPCGTC KMGAKDDPMA VVDPQTRVIG VEALRVADSS
510 520 530 540
IFPHVTYGNL NGPSIMTGEK AADHILGKQP LARSNQEPWV NPRAAVSDR
Length:549
Mass (Da):60,411
Last modified:November 25, 2008 - v1
Checksum:iE3D1869F1DE37DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI54071.1.
RefSeqiWP_012556953.1. NC_011369.1.

Genome annotation databases

EnsemblBacteriaiACI54071; ACI54071; Rleg2_0776.
KEGGirlt:Rleg2_0776.
PATRICi23125438. VBIRhiLeg95088_2562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI54071.1.
RefSeqiWP_012556953.1. NC_011369.1.

3D structure databases

ProteinModelPortaliB5ZUG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395492.Rleg2_0776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI54071; ACI54071; Rleg2_0776.
KEGGirlt:Rleg2_0776.
PATRICi23125438. VBIRhiLeg95088_2562.

Phylogenomic databases

eggNOGiENOG4105CZ6. Bacteria.
COG2303. LUCA.
HOGENOMiHOG000139600.
KOiK00108.
OMAiWPEYDFI.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00750. Choline_dehydrogen. 1 hit.
InterProiIPR011533. BetA.
IPR023753. FAD/NAD-binding_dom.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBETA_RHILW
AccessioniPrimary (citable) accession number: B5ZUG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.