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B5ZUG2 (BETA_RHILW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1
Gene names
Name:betA
Ordered Locus Names:Rleg2_0776
OrganismRhizobium leguminosarum bv. trifolii (strain WSM2304) [Complete proteome] [HAMAP]
Taxonomic identifier395492 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750

Cofactor

FAD By similarity. HAMAP MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Choline dehydrogenase HAMAP MF_00750
PRO_1000133337

Regions

Nucleotide binding4 – 3330FAD Potential

Sites

Active site4651 By similarity

Sequences

Sequence LengthMass (Da)Tools
B5ZUG2 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: E3D1869F1DE37DBB

FASTA54960,411
        10         20         30         40         50         60 
MQADFVIIGS GSAGSALAYR LSEDGKNSVL VIEAGGSDFG PFIQMPAALA WPMSMKRYNW 

        70         80         90        100        110        120 
GYLSEPEPNL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE DFNRWEELGA GGWAYADVLP 

       130        140        150        160        170        180 
YFKRMEHSHG GEEGWRGTDG PLHVQRGGFT NPLFRAFVEA GKQAGFETTE DYNGSKQEGF 

       190        200        210        220        230        240 
GLMEQTIFSG RRWSAANAYL KPALKRKNVE IIYGFAQRIV IEDGRATGVE IERGGKIEVV 

       250        260        270        280        290        300 
KANREVIVSA SSFNSPKLLM LSGIGPGEHL KEMGIEVKAD RPGVGANLQD HMEFYFQQVS 

       310        320        330        340        350        360 
TKPVSLYSWL PWFWQGVAGA QWLLSKGGLG ASNQFEACAF LRSAPGLKQP DIQYHFLPVA 

       370        380        390        400        410        420 
ISYDGKAAAK SHGFQVHVGY NLSKSRGSVT LRSPDPKADP VLRFNYMSHA EDWEKFRHCV 

       430        440        450        460        470        480 
RLTRELFGQA AFDDYRGAEI QPGESVQSDE EIDAFLREHL ESAYHPCGTC KMGAKDDPMA 

       490        500        510        520        530        540 
VVDPQTRVIG VEALRVADSS IFPHVTYGNL NGPSIMTGEK AADHILGKQP LARSNQEPWV 


NPRAAVSDR

« Hide

References

[1]"Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R. expand/collapse author list , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM2304.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001191 Genomic DNA. Translation: ACI54071.1.
RefSeqYP_002280297.1. NC_011369.1.

3D structure databases

ProteinModelPortalB5ZUG2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5ZUG2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6979494.
GenomeReviewsGene locus Rleg2_0776 in contig CP001191_GR.
KEGGrlt:Rleg2_0776.
PATRIC23125438. VBIRhiLeg95088_2562.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG734713.
OMAGPFIQMP.
ProtClustDBPRK02106.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
KOK00108.
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. BetA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_RHILW
AccessionPrimary (citable) accession number: B5ZUG2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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