B5ZSW0 (KHSE_RHILW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Rleg2_0612

Organism

Rhizobium leguminosarum bv. trifolii (strain WSM2304) [Complete proteome] [HAMAP]

Taxonomic identifier

395492 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000115440

Sequences

	Sequence		Length	Mass (Da)
	B5ZSW0 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: CF0E83F22C27CF37	FASTA	321	35,826
	10 20 30 40 50 60 MAVYTDIAED DLKWFLTEYD AGTLLSYKGI AEGVENSNFL LHTSKDPLIL TLYEKRVEKT 70 80 90 100 110 120 DLPFFLGLMQ HLSARGLSCP LPLPRRDGAL LGSLSGRPAA LISFLEGMWL RKPEAKHCRE 130 140 150 160 170 180 VGRALAEMHV AGDGFELKRP NALSIDGWQT LWEKSEARAG EVEAGLQDEI RGELDFLAAA 190 200 210 220 230 240 WPKNLPAGII HADLFPDNVF FLGDALSGLI DFYFACNDLL AYDVSICLNA WCFEKDGAYN 250 260 270 280 290 300 ITKGTAMLEG YQSVRPLSGE EIAALPVLSR GSALRFFLTR LYDWLTTPEG AMVTKKDPLE 310 320 YLRKLRFHRQ IKSPAEYGLS L

References

[1]

"Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R. , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WSM2304.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001191 Genomic DNA. Translation: ACI53909.1.
RefSeq	YP_002280135.1. NC_011369.1.
3D structure databases
ProteinModelPortal	B5ZSW0.
SMR	B5ZSW0. Positions 5-320.
ModBase	Search...
Protein-protein interaction databases
STRING	B5ZSW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6979328.
GenomeReviews	Gene locus Rleg2_0612 in contig CP001191_GR.
KEGG	rlt:Rleg2_0612.
PATRIC	23125100. VBIRhiLeg95088_2395.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHILW

Accession

Primary (citable) accession number: B5ZSW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program