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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105Proton acceptorUniRule annotation1
Binding sitei123SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:Rleg2_2013
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000976871 – 232Ribose-5-phosphate isomerase AAdd BLAST232

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi395492.Rleg2_2013

Structurei

3D structure databases

ProteinModelPortaliB5ZRL6
SMRiB5ZRL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 31Substrate bindingUniRule annotation4
Regioni83 – 86Substrate bindingUniRule annotation4
Regioni96 – 99Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66 Bacteria
COG0120 LUCA
HOGENOMiHOG000276369
KOiK01807
OMAiVAPMAYV

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

B5ZRL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAREMKIKA AAAALAHVED GMRLGIGTGS TAEEFVRLLA EKVASGFKVE
60 70 80 90 100
GVPTSERTAR LCVELGVPLK SLDELPALDL TIDGADEVDP ALRLIKGGGG
110 120 130 140 150
ALLREKIVAA ASERMIVIAD ESKLVDTLGA YALPIEVNPF GLVSTRIAIE
160 170 180 190 200
KVAARLGLAG ELSLRQSGDG EFTTDGGHHI IDASFGRIPD AEALSSELNS
210 220 230
IPGVVEHGLF INMAALAIIA GPAGARTLQA NR
Length:232
Mass (Da):24,113
Last modified:November 25, 2008 - v1
Checksum:iA084B4DF751BA9DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA Translation: ACI55297.1
RefSeqiWP_012557870.1, NC_011369.1

Genome annotation databases

EnsemblBacteriaiACI55297; ACI55297; Rleg2_2013
GeneIDi34191436
KEGGirlt:Rleg2_2013

Similar proteinsi

Entry informationi

Entry nameiRPIA_RHILW
AccessioniPrimary (citable) accession number: B5ZRL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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