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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2252-MONOMER.
RLEG395492:GJB3-1922-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Rleg2_1891
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008330 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000132449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi395492.Rleg2_1891.

Structurei

3D structure databases

ProteinModelPortaliB5ZQP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B5ZQP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPTEFQFT DYQPYDFANR RHIGPSPAEM TDMLKVIGYN SLDGLIDGTL
60 70 80 90 100
PPAIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYHGTITPP
110 120 130 140 150
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMVCD LTGLDVANAS
160 170 180 190 200
LLDEATAAAE GMAIAERVAK SKAKAFFVDA DCHPQTIALI RTRAEPLGWQ
210 220 230 240 250
VIVGNPFTDL DPVDVFGAIF QYPGTHGHIN DFTGLIARLH QAGAISIVAA
260 270 280 290 300
DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAYM AVKDAIKRSM
310 320 330 340 350
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM
360 370 380 390 400
YAVFHGPKGI KAIAQQVHQK AVLMAKGLEK LGYKVEPESF FDTITVDVGH
410 420 430 440 450
MQGLILRAAV AEGVNLRKVG DTHIGMSLDE RTRPATLEAV WRAFGGNFKI
460 470 480 490 500
ADFEPSYRLP KGLLRTSDYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR
510 520 530 540 550
SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG YREMIDDLIE
560 570 580 590 600
KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NFHIANGEGH RDVCLIPTSA
610 620 630 640 650
HGTNPASAQM VGMKVVVVKV RENGDIDLDD FRAKAEEHAA NLSCCMITYP
660 670 680 690 700
STHGVFEETV KEICDLVHAN GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKAHLAPHL PGHPETDGRP GAVSAAAFGS
760 770 780 790 800
ASILPISWSY CLMMGGEGLT QATKVAILNA NYIATRLKGA YDVLYKSKTG
810 820 830 840 850
RVAHECIIDT RPLVDSAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP
860 870 880 890 900
TESETKAELD RFCEAMLAIR EEARAIEDGR MDKVNNPLKN APHTVEDLVG
910 920 930 940 950
EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA

EAAE
Length:954
Mass (Da):103,878
Last modified:November 25, 2008 - v1
Checksum:i657DB783103313E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI55176.1.
RefSeqiYP_002281402.1. NC_011369.1.

Genome annotation databases

EnsemblBacteriaiACI55176; ACI55176; Rleg2_1891.
KEGGirlt:Rleg2_1891.
PATRICi23127824. VBIRhiLeg95088_3734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI55176.1.
RefSeqiYP_002281402.1. NC_011369.1.

3D structure databases

ProteinModelPortaliB5ZQP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395492.Rleg2_1891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI55176; ACI55176; Rleg2_1891.
KEGGirlt:Rleg2_1891.
PATRICi23127824. VBIRhiLeg95088_3734.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2252-MONOMER.
RLEG395492:GJB3-1922-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
    , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM2304.

Entry informationi

Entry nameiGCSP_RHILW
AccessioniPrimary (citable) accession number: B5ZQP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.