Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B5ZQP8

- GCSP_RHILW

UniProt

B5ZQP8 - GCSP_RHILW

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-2252-MONOMER.
    RLEG395492:GJB3-1922-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Rleg2_1891
    OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
    Taxonomic identifieri395492 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008330: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000132449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi395492.Rleg2_1891.

    Structurei

    3D structure databases

    ProteinModelPortaliB5ZQP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5ZQP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTPTEFQFT DYQPYDFANR RHIGPSPAEM TDMLKVIGYN SLDGLIDGTL    50
    PPAIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYHGTITPP 100
    VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMVCD LTGLDVANAS 150
    LLDEATAAAE GMAIAERVAK SKAKAFFVDA DCHPQTIALI RTRAEPLGWQ 200
    VIVGNPFTDL DPVDVFGAIF QYPGTHGHIN DFTGLIARLH QAGAISIVAA 250
    DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAYM AVKDAIKRSM 300
    PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
    YAVFHGPKGI KAIAQQVHQK AVLMAKGLEK LGYKVEPESF FDTITVDVGH 400
    MQGLILRAAV AEGVNLRKVG DTHIGMSLDE RTRPATLEAV WRAFGGNFKI 450
    ADFEPSYRLP KGLLRTSDYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
    SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG YREMIDDLIE 550
    KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NFHIANGEGH RDVCLIPTSA 600
    HGTNPASAQM VGMKVVVVKV RENGDIDLDD FRAKAEEHAA NLSCCMITYP 650
    STHGVFEETV KEICDLVHAN GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKAHLAPHL PGHPETDGRP GAVSAAAFGS 750
    ASILPISWSY CLMMGGEGLT QATKVAILNA NYIATRLKGA YDVLYKSKTG 800
    RVAHECIIDT RPLVDSAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
    TESETKAELD RFCEAMLAIR EEARAIEDGR MDKVNNPLKN APHTVEDLVG 900
    EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA 950
    EAAE 954
    Length:954
    Mass (Da):103,878
    Last modified:November 25, 2008 - v1
    Checksum:i657DB783103313E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001191 Genomic DNA. Translation: ACI55176.1.
    RefSeqiYP_002281402.1. NC_011369.1.

    Genome annotation databases

    EnsemblBacteriaiACI55176; ACI55176; Rleg2_1891.
    GeneIDi6980630.
    KEGGirlt:Rleg2_1891.
    PATRICi23127824. VBIRhiLeg95088_3734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001191 Genomic DNA. Translation: ACI55176.1 .
    RefSeqi YP_002281402.1. NC_011369.1.

    3D structure databases

    ProteinModelPortali B5ZQP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395492.Rleg2_1891.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI55176 ; ACI55176 ; Rleg2_1891 .
    GeneIDi 6980630.
    KEGGi rlt:Rleg2_1891.
    PATRICi 23127824. VBIRhiLeg95088_3734.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-2252-MONOMER.
    RLEG395492:GJB3-1922-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
      , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM2304.

    Entry informationi

    Entry nameiGCSP_RHILW
    AccessioniPrimary (citable) accession number: B5ZQP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3