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B5ZPG3 (HEMH_RHILW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Rleg2_3304
OrganismRhizobium leguminosarum bv. trifolii (strain WSM2304) [Complete proteome] [HAMAP]
Taxonomic identifier395492 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Ferrochelatase HAMAP MF_00323
PRO_1000116071

Sites

Metal binding2141Iron By similarity
Metal binding2951Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B5ZPG3 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: DA5451EB3686804A

FASTA34439,549
        10         20         30         40         50         60 
MTADTSLRPA DHPAVKSGKV GVLLVNLGTP DGTDYTSMRR YLREFLTDRR VIEWSPWKWY 

        70         80         90        100        110        120 
PILFGVVLNT RPRKVGKAYE LIWNKEKNES YLRTYTRNQS ELMAEHLKDL ATVKVDWAMR 

       130        140        150        160        170        180 
YGTPSIASRI EALKQEGCDR IVLFPLYPQY AAATTATVND KAFQKLLSMR WQPALRTVPD 

       190        200        210        220        230        240 
YHDDETYIEA LATSVEKHLA TLDWKPEMLL ASFHGIPMSY FKQGDPYYCQ CQKTGRLLRE 

       250        260        270        280        290        300 
RLGLTKENFM VTFQSRFGPE EWLQPYTDKT VEKLAQDGVK RIAVINPGFV SDCLETLEEI 

       310        320        330        340 
AEQAAHSFHE NGGEKFAHIP CLNDGEDGMT VLEKVVRREL QGWI

« Hide

References

[1]"Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R. expand/collapse author list , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM2304.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001191 Genomic DNA. Translation: ACI56571.1.
RefSeqYP_002282797.1. NC_011369.1.

3D structure databases

ProteinModelPortalB5ZPG3.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5ZPG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6982057.
GenomeReviewsGene locus Rleg2_3304 in contig CP001191_GR.
KEGGrlt:Rleg2_3304.
PATRIC23130820. VBIRhiLeg95088_5220.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_RHILW
AccessionPrimary (citable) accession number: B5ZPG3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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