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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei255ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:UUR10_0704
OrganismiUreaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Taxonomic identifieri565575 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
Proteomesi
  • UP000002018 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000901191 – 482Glutamate--tRNA ligaseAdd BLAST482

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi565575.UUR10_0704

Structurei

3D structure databases

ProteinModelPortaliB5ZCB4
SMRiB5ZCB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi252 – 256"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B5ZCB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRTRYAPS PTGYLHIGGA RTALFNYLLA KAYDGDFIIR IEDTDVERNV
60 70 80 90 100
EGGIDSQFNF LEWMGIVADE SIRNPKTFGP YIQSQKLKHY EALALDLVAQ
110 120 130 140 150
KKAYFCFCSK ERLDADRELA EKLHETPKYK RHCLNLNEQT IQANLLANKE
160 170 180 190 200
YTIRLKIDEN NEYSWDDLIR GKISIPGSAL TDPVILKSNK IAMYNFAVVI
210 220 230 240 250
DDYEMQISHV IRGEEHISNT PYQLAIAQAL NYDLSKIKYG HLSIIVDETG
260 270 280 290 300
KKLSKRNLAL KQFVSDYEKD GYWPHAITNF VALLGWSPKN NQEIMSLVEM
310 320 330 340 350
VENFDVNNLS KSPAFFDINK MNWFSTQYFN NISQDEFIDF VKTHPLTKEL
360 370 380 390 400
VLKDTTFIDK ALLFKSHIVN LKQLINLVDE QFNSNKQLLE EDVNHIKNNQ
410 420 430 440 450
LTNVVQVFYE QLIVSEKFDE QSIKEVIKQV QKTTNNKGAN LYMPIRIATT
460 470 480
FSSHGPELAK TIYYLGRENV LKNLQSILKV LG
Length:482
Mass (Da):55,593
Last modified:November 25, 2008 - v1
Checksum:iE699C2AD35A1973C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001184 Genomic DNA Translation: ACI60133.1
RefSeqiWP_004026196.1, NC_011374.1

Genome annotation databases

EnsemblBacteriaiACI60133; ACI60133; UUR10_0704
KEGGiuue:UUR10_0704

Similar proteinsi

Entry informationi

Entry nameiSYE_UREU1
AccessioniPrimary (citable) accession number: B5ZCB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health