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B5ZCB4

- SYE_UREU1

UniProt

B5ZCB4 - SYE_UREU1

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei255 – 2551ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciUURE565575:GBZS-690-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:UUR10_0704
    OrganismiUreaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
    Taxonomic identifieri565575 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
    ProteomesiUP000002018: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482Glutamate--tRNA ligasePRO_1000090119Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi565575.UUR10_0704.

    Structurei

    3D structure databases

    ProteinModelPortaliB5ZCB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi9 – 1911"HIGH" regionAdd
    BLAST
    Motifi252 – 2565"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiKHYDGDF.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5ZCB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIRTRYAPS PTGYLHIGGA RTALFNYLLA KAYDGDFIIR IEDTDVERNV    50
    EGGIDSQFNF LEWMGIVADE SIRNPKTFGP YIQSQKLKHY EALALDLVAQ 100
    KKAYFCFCSK ERLDADRELA EKLHETPKYK RHCLNLNEQT IQANLLANKE 150
    YTIRLKIDEN NEYSWDDLIR GKISIPGSAL TDPVILKSNK IAMYNFAVVI 200
    DDYEMQISHV IRGEEHISNT PYQLAIAQAL NYDLSKIKYG HLSIIVDETG 250
    KKLSKRNLAL KQFVSDYEKD GYWPHAITNF VALLGWSPKN NQEIMSLVEM 300
    VENFDVNNLS KSPAFFDINK MNWFSTQYFN NISQDEFIDF VKTHPLTKEL 350
    VLKDTTFIDK ALLFKSHIVN LKQLINLVDE QFNSNKQLLE EDVNHIKNNQ 400
    LTNVVQVFYE QLIVSEKFDE QSIKEVIKQV QKTTNNKGAN LYMPIRIATT 450
    FSSHGPELAK TIYYLGRENV LKNLQSILKV LG 482
    Length:482
    Mass (Da):55,593
    Last modified:November 25, 2008 - v1
    Checksum:iE699C2AD35A1973C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001184 Genomic DNA. Translation: ACI60133.1.
    RefSeqiYP_002285054.1. NC_011374.1.

    Genome annotation databases

    EnsemblBacteriaiACI60133; ACI60133; UUR10_0704.
    GeneIDi6984189.
    KEGGiuue:UUR10_0704.
    PATRICi20536264. VBIUreUre98799_0672.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001184 Genomic DNA. Translation: ACI60133.1 .
    RefSeqi YP_002285054.1. NC_011374.1.

    3D structure databases

    ProteinModelPortali B5ZCB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 565575.UUR10_0704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI60133 ; ACI60133 ; UUR10_0704 .
    GeneIDi 6984189.
    KEGGi uue:UUR10_0704.
    PATRICi 20536264. VBIUreUre98799_0672.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi KHYDGDF.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci UURE565575:GBZS-690-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699."
      Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33699 / Western.

    Entry informationi

    Entry nameiSYE_UREU1
    AccessioniPrimary (citable) accession number: B5ZCB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3