B5ZCA9 (KITH_UREU1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	UUR10_0699

Organism

Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western) [Complete proteome] [HAMAP]

Taxonomic identifier

565575 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Ureaplasma › Ureaplasma urealyticum › Ureaplasma urealyticum serovar 10

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Thymidine kinase HAMAP-Rule MF_00124		PRO_1000095439
Regions
	Nucleotide binding	19 – 26	8	ATP By similarity
	Nucleotide binding	96 – 99	4	ATP By similarity
Sites
	Active site	97	1	Proton acceptor Potential
	Metal binding	153	1	Zinc By similarity
	Metal binding	156	1	Zinc By similarity
	Metal binding	191	1	Zinc By similarity
	Metal binding	194	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5ZCA9 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: F74B4D892475FF26	FASTA	223	25,398
	10 20 30 40 50 60 MAKAHAFSKK VGWIELITGP MFAGKTAELI RRLHRLEYAD VKYLVFKPRI DTRSTQNIKS 70 80 90 100 110 120 RTGTSLPSIE VENAPEILSY IMSDNFDNEI KVIGIDEVQF FDDRICEVAN ILAENGFVVI 130 140 150 160 170 180 ISGLDKNFKG EPFGPIAKLF AYADKITKLT AICNECGAEA THSLRKIDGK YANYDDEIVK 190 200 210 220 IGCQEFYSAV CRHHHKVPNR PYLNANSEEF IRFFKNKKRN KNV

References

[1]	"Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699." Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33699 / Western.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001184 Genomic DNA. Translation: ACI59923.1.
RefSeq	YP_002285049.1. NC_011374.1.
3D structure databases
ProteinModelPortal	B5ZCA9.
SMR	B5ZCA9. Positions 11-217.
ModBase	Search...
Protein-protein interaction databases
STRING	565575.UUR10_0699.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACI59923; ACI59923; UUR10_0699.
GeneID	6983744.
KEGG	uue:UUR10_0699.
PATRIC	20536254. VBIUreUre98799_0667.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076390.
KO	K00857.
OMA	ELICGSM.
ProtClustDB	PRK04296.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_UREU1

Accession

Primary (citable) accession number: B5ZCA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program