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B5ZCA9 (KITH_UREU1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:UUR10_0699
OrganismUreaplasma urealyticum serovar 10 (strain ATCC 33699 / Western) [Complete proteome] [HAMAP]
Taxonomic identifier565575 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Thymidine kinase HAMAP-Rule MF_00124
PRO_1000095439

Regions

Nucleotide binding19 – 268ATP By similarity
Nucleotide binding96 – 994ATP By similarity

Sites

Active site971Proton acceptor Potential
Metal binding1531Zinc By similarity
Metal binding1561Zinc By similarity
Metal binding1911Zinc By similarity
Metal binding1941Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
B5ZCA9 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: F74B4D892475FF26

FASTA22325,398
        10         20         30         40         50         60 
MAKAHAFSKK VGWIELITGP MFAGKTAELI RRLHRLEYAD VKYLVFKPRI DTRSTQNIKS 

        70         80         90        100        110        120 
RTGTSLPSIE VENAPEILSY IMSDNFDNEI KVIGIDEVQF FDDRICEVAN ILAENGFVVI 

       130        140        150        160        170        180 
ISGLDKNFKG EPFGPIAKLF AYADKITKLT AICNECGAEA THSLRKIDGK YANYDDEIVK 

       190        200        210        220 
IGCQEFYSAV CRHHHKVPNR PYLNANSEEF IRFFKNKKRN KNV 

« Hide

References

[1]"Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699."
Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33699 / Western.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001184 Genomic DNA. Translation: ACI59923.1.
RefSeqYP_002285049.1. NC_011374.1.

3D structure databases

ProteinModelPortalB5ZCA9.
SMRB5ZCA9. Positions 11-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING565575.UUR10_0699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI59923; ACI59923; UUR10_0699.
GeneID6983744.
KEGGuue:UUR10_0699.
PATRIC20536254. VBIUreUre98799_0667.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMAELICGSM.
OrthoDBEOG69D3J2.
ProtClustDBPRK04296.

Enzyme and pathway databases

BioCycUURE565575:GBZS-685-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_UREU1
AccessionPrimary (citable) accession number: B5ZCA9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families