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Protein

Urease subunit alpha

Gene

ureC

Organism
Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit gamma (ureA)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi143Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi223Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi223Nickel 2; via carbamate groupUniRule annotation1
Binding sitei225SubstrateUniRule annotation1
Metal bindingi252Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi278Nickel 2; via tele nitrogenUniRule annotation1
Active sitei326Proton donorUniRule annotation1
Metal bindingi366Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:UUR10_0477
OrganismiUreaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Taxonomic identifieri565575 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
Proteomesi
  • UP000002018 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001888961 – 598Urease subunit alphaAdd BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi565575.UUR10_0477.

Structurei

3D structure databases

ProteinModelPortaliB5ZBS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 598UreaseUniRule annotationAdd BLAST463

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 1 hit.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZBS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKISRKNYS DLYGITTGDS VRLGDTNLWV KVEKDLTTYG EESVFGGGKT
60 70 80 90 100
LREGMGMNST MKLDDKLGNA EVMDLVITNA LILDYTGIYK ADIGIKNGKI
110 120 130 140 150
ASIGKSGNPH LTDGVDMVVG ISTEVSAGEG KIYTAGGLDT HVHWLEPEIV
160 170 180 190 200
PVALDGGITT VIAGGTGMND GTKATTVSPG KFWVKSALQA ADGLPINAGF
210 220 230 240 250
LAKGQGMEDP IFEQIVAGAC GLKIHEDWGA TGNAIDLALT VAEKTDVAVA
260 270 280 290 300
IHTDTLNEAG FVEHTIAAMK GRTIHAYHTE GAGGGHAPDI LESVKYAHIL
310 320 330 340 350
PASTNPTIPY TVNTIAEHLD MLMVCHHLNP KVPEDVAFAD SRIRSQTIAA
360 370 380 390 400
EDLLHDMGAI SIMSSDTLAM GRIGEVVTRS WQMAHKMKAQ FGALKGDSEF
410 420 430 440 450
NDNNRVKRYV AKYTINPAIA HGIDSYVGSI EVGKLADIVA WEPKFFGAKP
460 470 480 490 500
YYVVKMGVIA RCVAGDPNAS IPTCEPVIMR DQFGTYGRSL TSTSVSFVSK
510 520 530 540 550
IGLENGIKEE YKLEKELLPV KNCRSINKKS MKWNSATPNL EVDPQTFDAA
560 570 580 590
VDYNDLENWL EQPAAELAKK LKKTANGKYV LDAEPLTEAP LAQRYFLF
Length:598
Mass (Da):64,491
Last modified:November 25, 2008 - v1
Checksum:i1BF5DB65636CBDB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085726 Genomic DNA. Translation: AAD28124.2.
CP001184 Genomic DNA. Translation: ACI59907.1.
RefSeqiWP_004025654.1. NC_011374.1.

Genome annotation databases

EnsemblBacteriaiACI59907; ACI59907; UUR10_0477.
KEGGiuue:UUR10_0477.
PATRICi20535804. VBIUreUre98799_0463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085726 Genomic DNA. Translation: AAD28124.2.
CP001184 Genomic DNA. Translation: ACI59907.1.
RefSeqiWP_004025654.1. NC_011374.1.

3D structure databases

ProteinModelPortaliB5ZBS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi565575.UUR10_0477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI59907; ACI59907; UUR10_0477.
KEGGiuue:UUR10_0477.
PATRICi20535804. VBIUreUre98799_0463.

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 1 hit.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURE1_UREU1
AccessioniPrimary (citable) accession number: B5ZBS9
Secondary accession number(s): P17272, Q56554, Q9R417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.