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B5ZBI3

- SYL_UREU1

UniProt

B5ZBI3 - SYL_UREU1

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Protein
Leucine--tRNA ligase
Gene
leuS, UUR10_0380
Organism
Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUURE565575:GBZS-379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:UUR10_0380
OrganismiUreaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Taxonomic identifieri565575 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000002018: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligaseUniRule annotation
PRO_1000091376Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi565575.UUR10_0380.

Structurei

3D structure databases

ProteinModelPortaliB5ZBI3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZBI3-1 [UniParc]FASTAAdd to Basket

« Hide

MYNHNKIEKK WQKYWLDNKT FKFVDNPNNP KKFYVLDMFP YPSGKGLHVG    50
HPKGYTATDV ISRFKRLNGY DVLHPIGWDA FGLPAEQYAL ETNNHPHTFT 100
QQNIKIFRKQ LQMIGFDFDY DKEVDTTDPQ FYQWTQWIFV QLYKHNLAEI 150
QDIDVNWCEN LGTVLSNEEV VLNDKNERVS ERGGHPVVRK PMKQWVLKIV 200
DYADKLLDGL NEVEFSESLK SLQRNWIGKS IGTNVQFKIK DSHLALDVFT 250
TRIDTIYGAQ YLVVAPEHPI LKSIVSEQQA SVVQAYVDQT KKISDLDRIA 300
DTNKTGVFSG TYAINPINQE IIPIWVSDYV LMNFATGAVM GVPAHDERDY 350
AFAKKYDLPI KSVIDTKQSL PYTGDGLHIN SPMINGLNIE QSQNILNDYL 400
VKNHLAKRVV NYKLRNWIFS RQRYWGEPFP VLFDENNQIK IIEDLPVLLP 450
NLDEFKPSKT GESPLANAQE WLYVEIDGKK YRRETNTMPQ WAGSSWYFLA 500
YILKNEDGSY TPLNSEEAKK RFAKWLPVDV YIGGQEHAVL HLLYARFWHR 550
FLYDIGVVPT KEPFYKVINQ GMILGENNEK MSKSKGNVIN PDDIIASHGA 600
DTLRIYEMFM GPLTASLPWS PDGLDAMRKW LDRVYRLYHN LSELEVVEDV 650
NKLNEEIIIT YHTLIKNYTK AINEQAFNIA ISEMMVFVNV LYKNKVINYK 700
LLDNFLILLS CFAPHLAEEL YSLNHSESVC LQKMPIYDEQ KIIAQNVTIP 750
IQINGKLKHT INVLRDTNAE QLINLALACE QVKQAIGDQP IKKQIVVVNK 800
IINFVI 806
Length:806
Mass (Da):93,235
Last modified:November 25, 2008 - v1
Checksum:iF067C46230A60CBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001184 Genomic DNA. Translation: ACI60167.1.
RefSeqiWP_012560305.1. NC_011374.1.
YP_002284773.1. NC_011374.1.

Genome annotation databases

EnsemblBacteriaiACI60167; ACI60167; UUR10_0380.
GeneIDi6983733.
KEGGiuue:UUR10_0380.
PATRICi20535606. VBIUreUre98799_0365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001184 Genomic DNA. Translation: ACI60167.1 .
RefSeqi WP_012560305.1. NC_011374.1.
YP_002284773.1. NC_011374.1.

3D structure databases

ProteinModelPortali B5ZBI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 565575.UUR10_0380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI60167 ; ACI60167 ; UUR10_0380 .
GeneIDi 6983733.
KEGGi uue:UUR10_0380.
PATRICi 20535606. VBIUreUre98799_0365.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci UURE565575:GBZS-379-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699."
    Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33699 / Western.

Entry informationi

Entry nameiSYL_UREU1
AccessioniPrimary (citable) accession number: B5ZBI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi