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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUURE565575:GBZS-379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:UUR10_0380
OrganismiUreaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Taxonomic identifieri565575 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000002018 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligasePRO_1000091376Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi565575.UUR10_0380.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi580 – 5845"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZBI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNHNKIEKK WQKYWLDNKT FKFVDNPNNP KKFYVLDMFP YPSGKGLHVG
60 70 80 90 100
HPKGYTATDV ISRFKRLNGY DVLHPIGWDA FGLPAEQYAL ETNNHPHTFT
110 120 130 140 150
QQNIKIFRKQ LQMIGFDFDY DKEVDTTDPQ FYQWTQWIFV QLYKHNLAEI
160 170 180 190 200
QDIDVNWCEN LGTVLSNEEV VLNDKNERVS ERGGHPVVRK PMKQWVLKIV
210 220 230 240 250
DYADKLLDGL NEVEFSESLK SLQRNWIGKS IGTNVQFKIK DSHLALDVFT
260 270 280 290 300
TRIDTIYGAQ YLVVAPEHPI LKSIVSEQQA SVVQAYVDQT KKISDLDRIA
310 320 330 340 350
DTNKTGVFSG TYAINPINQE IIPIWVSDYV LMNFATGAVM GVPAHDERDY
360 370 380 390 400
AFAKKYDLPI KSVIDTKQSL PYTGDGLHIN SPMINGLNIE QSQNILNDYL
410 420 430 440 450
VKNHLAKRVV NYKLRNWIFS RQRYWGEPFP VLFDENNQIK IIEDLPVLLP
460 470 480 490 500
NLDEFKPSKT GESPLANAQE WLYVEIDGKK YRRETNTMPQ WAGSSWYFLA
510 520 530 540 550
YILKNEDGSY TPLNSEEAKK RFAKWLPVDV YIGGQEHAVL HLLYARFWHR
560 570 580 590 600
FLYDIGVVPT KEPFYKVINQ GMILGENNEK MSKSKGNVIN PDDIIASHGA
610 620 630 640 650
DTLRIYEMFM GPLTASLPWS PDGLDAMRKW LDRVYRLYHN LSELEVVEDV
660 670 680 690 700
NKLNEEIIIT YHTLIKNYTK AINEQAFNIA ISEMMVFVNV LYKNKVINYK
710 720 730 740 750
LLDNFLILLS CFAPHLAEEL YSLNHSESVC LQKMPIYDEQ KIIAQNVTIP
760 770 780 790 800
IQINGKLKHT INVLRDTNAE QLINLALACE QVKQAIGDQP IKKQIVVVNK

IINFVI
Length:806
Mass (Da):93,235
Last modified:November 25, 2008 - v1
Checksum:iF067C46230A60CBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001184 Genomic DNA. Translation: ACI60167.1.
RefSeqiYP_002284773.1. NC_011374.1.

Genome annotation databases

EnsemblBacteriaiACI60167; ACI60167; UUR10_0380.
GeneIDi6983733.
KEGGiuue:UUR10_0380.
PATRICi20535606. VBIUreUre98799_0365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001184 Genomic DNA. Translation: ACI60167.1.
RefSeqiYP_002284773.1. NC_011374.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi565575.UUR10_0380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI60167; ACI60167; UUR10_0380.
GeneIDi6983733.
KEGGiuue:UUR10_0380.
PATRICi20535606. VBIUreUre98799_0365.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciUURE565575:GBZS-379-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699."
    Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33699 / Western.

Entry informationi

Entry nameiSYL_UREU1
AccessioniPrimary (citable) accession number: B5ZBI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: April 1, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.