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B5ZB79

- TRMB_UREU1

UniProt

B5ZB79 - TRMB_UREU1

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451S-adenosyl-L-methionineUniRule annotation
Binding sitei70 – 701S-adenosyl-L-methionineUniRule annotation
Binding sitei97 – 971S-adenosyl-L-methionineUniRule annotation
Active sitei119 – 1191By similarity
Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation
Binding sitei155 – 1551SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciUURE565575:GBZS-264-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:UUR10_0265
OrganismiUreaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)
Taxonomic identifieri565575 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000002018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_1000136374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi565575.UUR10_0265.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiGCGKGEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZB79 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLRNNANAP LYLKSQEQYI VNDQQLLKND LAKVFKNPHL PLHIEIGMGK
60 70 80 90 100
GDFIVENALH NPQINYLGIE KFPTVIVKAH KKALKHKLDN LAMICFDANA
110 120 130 140 150
ILDLLNSKSI DKIYLNFSDP WPKKRHAKKR LTNPYFLEKF AALLKDDGLI
160 170 180 190 200
EFKTDNESLF HYTIYDVLLN DLTKYEILFL TYNLYALVNN VELLKNIPTE
210 220
YEKKFVMQGQ RIKKVSFRFL KKND
Length:224
Mass (Da):26,258
Last modified:November 25, 2008 - v1
Checksum:i7D4F73EEF46E10CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001184 Genomic DNA. Translation: ACI60254.1.
RefSeqiYP_002284669.1. NC_011374.1.

Genome annotation databases

EnsemblBacteriaiACI60254; ACI60254; UUR10_0265.
GeneIDi6984076.
KEGGiuue:UUR10_0265.
PATRICi20535372. VBIUreUre98799_0257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001184 Genomic DNA. Translation: ACI60254.1 .
RefSeqi YP_002284669.1. NC_011374.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 565575.UUR10_0265.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI60254 ; ACI60254 ; UUR10_0265 .
GeneIDi 6984076.
KEGGi uue:UUR10_0265.
PATRICi 20535372. VBIUreUre98799_0257.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi GCGKGEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci UURE565575:GBZS-264-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699."
    Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33699 / Western.

Entry informationi

Entry nameiTRMB_UREU1
AccessioniPrimary (citable) accession number: B5ZB79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3