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B5Z9L3

- PDXA_HELPG

UniProt

B5Z9L3 - PDXA_HELPG

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, HPG27_1520
Organism
Helicobacter pylori (strain G27)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261Substrate By similarity
Binding sitei127 – 1271Substrate By similarity
Metal bindingi156 – 1561Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi195 – 1951Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi251 – 2511Divalent metal cation; shared with dimeric partner By similarity
Binding sitei259 – 2591Substrate By similarity
Binding sitei268 – 2681Substrate By similarity
Binding sitei277 – 2771Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciHPYL563041:GC38-1563-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:HPG27_1520
OrganismiHelicobacter pylori (strain G27)
Taxonomic identifieri563041 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000001735: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3073074-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_1000128252Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi563041.HPG27_1520.

Structurei

3D structure databases

ProteinModelPortaliB5Z9L3.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221591.
KOiK00097.
OMAiISIKLAM.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

B5Z9L3-1 [UniParc]FASTAAdd to Basket

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MAKKKIAISC GDIQGVGLEL ILKSHKEVNA FCEPLYLIDG ELLERANQLL    50
HNAYETKTLN TLAIHSPLPL LNSSTIGKVS AQSGAYSFES FKKACELADS 100
KEVDGICTLP INKLAWQQAQ IPFVGHTDFL KQRYKDHQII MMLGCSKLFV 150
GLFSDHVPLG AVSQLIQVKA LVKFLLAFQK STQAKIVQVC GFNPHAGEEG 200
LFGKEDEKIL KAIQKSNQTL GFECFLGPLP ADSAFAPNKR QITPFYVSMS 250
HDVGLAPLKA LYFDESINVS LNAPILRAST DHGTAFDIAY QNKANNKSYL 300
NAIKYLA 307
Length:307
Mass (Da):33,734
Last modified:November 25, 2008 - v1
Checksum:i0A8730B63654DDB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001173 Genomic DNA. Translation: ACI28262.1.
RefSeqiWP_001074972.1. NC_011333.1.
YP_002267128.1. NC_011333.1.

Genome annotation databases

EnsemblBacteriaiACI28262; ACI28262; HPG27_1520.
GeneIDi6964440.
KEGGihpg:HPG27_1520.
PATRICi20601242. VBIHelPyl113476_1648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001173 Genomic DNA. Translation: ACI28262.1 .
RefSeqi WP_001074972.1. NC_011333.1.
YP_002267128.1. NC_011333.1.

3D structure databases

ProteinModelPortali B5Z9L3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 563041.HPG27_1520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI28262 ; ACI28262 ; HPG27_1520 .
GeneIDi 6964440.
KEGGi hpg:HPG27_1520.
PATRICi 20601242. VBIHelPyl113476_1648.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221591.
KOi K00097.
OMAi ISIKLAM.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci HPYL563041:GC38-1563-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G27.

Entry informationi

Entry nameiPDXA_HELPG
AccessioniPrimary (citable) accession number: B5Z9L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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