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B5Z8L0

- PNP_HELPG

UniProt

B5Z8L0 - PNP_HELPG

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Helicobacter pylori (strain G27)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi484 – 4841MagnesiumUniRule annotation
    Metal bindingi490 – 4901MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciHPYL563041:GC38-1198-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:HPG27_1159
    OrganismiHelicobacter pylori (strain G27)
    Taxonomic identifieri563041 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000001735: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 688688Polyribonucleotide nucleotidyltransferasePRO_0000381901Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi563041.HPG27_1159.

    Structurei

    3D structure databases

    ProteinModelPortaliB5Z8L0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini550 – 60960KHUniRule annotationAdd
    BLAST
    Domaini626 – 68863S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5Z8L0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFITINSSN KTEEFALKQV AKQATSSLMY RLGKTIILAS VCVEREPVSE    50
    DFLPLVVQFL EKSYAAGKIP GGFVKREGRA QDFEILTSRL IDRTFRPLFP 100
    KDYRYPTQIT LMVLSHDIEN DLQVSALNAA SVALFLAHIA PIKSVSACRI 150
    ARIDDEFIIN PNTSLLNQSS LDLFVSGTKE SLNMIEMRSL GQKLNALEEP 200
    LMLKALELAQ KSLKETCTLY EEVFTPHQNE LLFKESQGII FNERLLDLLK 250
    NQYFDEIIKG IESSALSERE NVFHEIAKKI SEAHSEFSLE EIEWSLEKVK 300
    KTEIRRMIIQ DKIRPDKRAL EEVRPILIES DLLPMAHSSI LFTRGQTQSL 350
    VVGVLGTDND AQTHESLEHK TPIKERFMFH YNFPPFCVGE ASSIGAASRR 400
    ELGHGNLAKR ALETSIKNKE QVIRLVSEIL ESNGSSSMAS VCAGSLALYA 450
    SGVEIHDLVA GVAMGMVSEG QDYAILSDIS GLEDAEGDMD FKIAGNLEGI 500
    TAMQMDTKMS GIQLEILYQA LLQAKEARKH ILKIMHEAKE KIVINFSHLP 550
    TTEIFNVAPD KIVEIIGQGG RVIKEIVEKF EVKIDLNKPS GEVKIMGNKE 600
    RVLKTKEFIL NYLHSLDQEL EQYTIDEVLE AQVKRIVDFG AFLSLPKGGE 650
    GLLRKQNMDR CQVVLREGDS IRCRVISFNK GKIALDLA 688
    Length:688
    Mass (Da):77,163
    Last modified:November 25, 2008 - v1
    Checksum:iAFCBA8FD5C2F1354
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001173 Genomic DNA. Translation: ACI27909.1.
    RefSeqiWP_000345848.1. NC_011333.1.
    YP_002266775.1. NC_011333.1.

    Genome annotation databases

    EnsemblBacteriaiACI27909; ACI27909; HPG27_1159.
    GeneIDi6964075.
    KEGGihpg:HPG27_1159.
    PATRICi20600456. VBIHelPyl113476_1259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001173 Genomic DNA. Translation: ACI27909.1 .
    RefSeqi WP_000345848.1. NC_011333.1.
    YP_002266775.1. NC_011333.1.

    3D structure databases

    ProteinModelPortali B5Z8L0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 563041.HPG27_1159.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI27909 ; ACI27909 ; HPG27_1159 .
    GeneIDi 6964075.
    KEGGi hpg:HPG27_1159.
    PATRICi 20600456. VBIHelPyl113476_1259.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci HPYL563041:GC38-1198-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G27.

    Entry informationi

    Entry nameiPNP_HELPG
    AccessioniPrimary (citable) accession number: B5Z8L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3