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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Helicobacter pylori (strain G27)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei4Purine nucleoside; shared with dimeric partnerBy similarity1
Binding sitei20Phosphate; via amide nitrogenBy similarity1
Binding sitei24PhosphateBy similarity1
Binding sitei43Phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
Ordered Locus Names:HPG27_1121
OrganismiHelicobacter pylori (strain G27)
Taxonomic identifieri563041 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000001735 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001862011 – 233Purine nucleoside phosphorylase DeoD-typeAdd BLAST233

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5Z8H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 90Phosphate bindingBy similarity4
Regioni179 – 181Purine nucleoside bindingBy similarity3
Regioni203 – 204Purine nucleoside bindingBy similarity2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000274896.
KOiK03784.
OMAiPQCLLCG.
OrthoDBiPOG091H02M1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5Z8H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPHINAKIG DFYPQCLLCG DPLRVSYIAK KFLQDAKEIT NVRNMLGFSG
60 70 80 90 100
KYKGKGISLM GHGMGIASCT IYVTELIKTY QVKELLRIGT CGAISPKVGL
110 120 130 140 150
KDIIMAIGAS TDSKTNRVRF LNHDLSATPD FELSLRAYQT AKRLGIDLKI
160 170 180 190 200
GNVFSSDFFY SFETHAFDLM AQYNHLAIEM EAAGLYATAM ELSAKALCLC
210 220 230
SVSDHLITKE ALSPKERVES FDNMITLALE MMS
Length:233
Mass (Da):25,745
Last modified:November 25, 2008 - v1
Checksum:iE63D25252FA723CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001173 Genomic DNA. Translation: ACI27871.1.
RefSeqiWP_000187664.1. NC_011333.1.

Genome annotation databases

EnsemblBacteriaiACI27871; ACI27871; HPG27_1121.
KEGGihpg:HPG27_1121.
PATRICi20600364. VBIHelPyl113476_1221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001173 Genomic DNA. Translation: ACI27871.1.
RefSeqiWP_000187664.1. NC_011333.1.

3D structure databases

ProteinModelPortaliB5Z8H2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI27871; ACI27871; HPG27_1121.
KEGGihpg:HPG27_1121.
PATRICi20600364. VBIHelPyl113476_1221.

Phylogenomic databases

HOGENOMiHOG000274896.
KOiK03784.
OMAiPQCLLCG.
OrthoDBiPOG091H02M1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEOD_HELPG
AccessioniPrimary (citable) accession number: B5Z8H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.