B5Z850 (AROA_HELPG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	HPG27_996

Organism

Helicobacter pylori (strain G27) [Complete proteome] [HAMAP]

Taxonomic identifier

563041 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099706

Sequences

	Sequence		Length	Mass (Da)
	B5Z850 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 6C5404C7E4F94F9B	FASTA	429	47,145
	10 20 30 40 50 60 MIELDINASD KSLSHRAVIF SLLAQKPCFV RNFLMGEDCL SSLEIAQNLG AKVENTAKNS 70 80 90 100 110 120 FKITPPTAIK EPNKILNCNN SGTSMRLYSG LLSAQKGLFV LSGDNSLNAR PMKRIIEPLK 130 140 150 160 170 180 AFGAKILGRE DNHFAPLAIL GSPLKACDYE SPIASAQVKS AFILSALQAQ GISAYKENEL 190 200 210 220 230 240 SRNHTEIMLK SLGADIQNQN GVLMISPLEK PLEAFDFTIA NDPSSAFFFA LACAITPKSR 250 260 270 280 290 300 LLLKNVLLNP TRIEAFEVLK KMGASIEYAI QSKDLEIIGD IYIEHAPLKA ISIDQNIASL 310 320 330 340 350 360 IDEIPALSIA MLFAKGKSMV KNAKDLRSKE SDRIKAVVSN LKALGIECEE FEDGFYIEGL 370 380 390 400 410 420 EDISPLKQHL SQKKPPLIQS FNDHRIAMSF AILTLALPLE IDNLECANIS FPQFKRLLNQ FKKGSFNGN

References

[1]

"The complete genome sequence of Helicobacter pylori strain G27." Baltrus D.A., Amieva M.R., Covacci A., Lowe T.M., Merrell D.S., Ottemann K.M., Stein M., Salama N.R., Guillemin K. J. Bacteriol. 191:447-448(2009) [PubMed: 18952803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001173 Genomic DNA. Translation: ACI27749.1.
RefSeq	YP_002266615.1. NC_011333.1.
3D structure databases
ProteinModelPortal	B5Z850.
ModBase	Search...
Protein-protein interaction databases
STRING	B5Z850.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6963900.
GenomeReviews	Gene locus HPG27_996 in contig CP001173_GR.
KEGG	hpg:HPG27_996.
PATRIC	20600086. VBIHelPyl113476_1086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	LECANIS.
ProtClustDB	PRK02427.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_HELPG

Accession

Primary (citable) accession number: B5Z850

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program