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B5Z7K9

- THIM_HELPG

UniProt

B5Z7K9 - THIM_HELPG

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Helicobacter pylori (strain G27)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381Substrate; via amide nitrogenUniRule annotation
    Binding sitei114 – 1141ATPUniRule annotation
    Binding sitei159 – 1591ATPUniRule annotation
    Binding sitei186 – 1861Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL563041:GC38-817-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:HPG27_803
    OrganismiHelicobacter pylori (strain G27)
    Taxonomic identifieri563041 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000001735: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Hydroxyethylthiazole kinasePRO_1000100415Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi563041.HPG27_803.

    Structurei

    3D structure databases

    ProteinModelPortaliB5Z7K9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiQTFTANV.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5Z7K9-1 [UniParc]FASTAAdd to Basket

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    MVLKELRQKR PLVHNITNYV VAQFVANGLL ALGASPLMSD AIDEMQDLAK    50
    ISDALAINIG TLNERTILCA KEAIKHYKAL NKPIVLDPVG CSASALRHDT 100
    SLELLESEGI SALRGNAAEL GSLVGISCES KGLDSHDATT PVEIIKRAAQ 150
    KYSVIAVMTG KTDYVSDGKK VLSITGGSEY LALITGAGCL HAAACASFLG 200
    LKKDPLDSMV QLCALYKQAA FSAQKKVLEN NGSNGSFLFY FLDALSLPIK 250
    LENSLIKEEW 260
    Length:260
    Mass (Da):27,797
    Last modified:November 25, 2008 - v1
    Checksum:iAE7D6BB01F0D6E1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001173 Genomic DNA. Translation: ACI27558.1.
    RefSeqiYP_002266424.1. NC_011333.1.

    Genome annotation databases

    EnsemblBacteriaiACI27558; ACI27558; HPG27_803.
    GeneIDi6963694.
    KEGGihpg:HPG27_803.
    PATRICi20599614. VBIHelPyl113476_0861.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001173 Genomic DNA. Translation: ACI27558.1 .
    RefSeqi YP_002266424.1. NC_011333.1.

    3D structure databases

    ProteinModelPortali B5Z7K9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 563041.HPG27_803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI27558 ; ACI27558 ; HPG27_803 .
    GeneIDi 6963694.
    KEGGi hpg:HPG27_803.
    PATRICi 20599614. VBIHelPyl113476_0861.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi QTFTANV.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci HPYL563041:GC38-817-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G27.

    Entry informationi

    Entry nameiTHIM_HELPG
    AccessioniPrimary (citable) accession number: B5Z7K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3