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B5Z7A0 (B5Z7A0_HELPG) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:HPG27_694 EMBL ACI27449.1
OrganismHelicobacter pylori (strain G27) [Complete proteome] [HAMAP] EMBL ACI27449.1
Taxonomic identifier563041 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain136 – 334199ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding163 – 21856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2901Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3021Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3021Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3041Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
B5Z7A0 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: AC8AE6297D082F1D

FASTA34939,948
        10         20         30         40         50         60 
MIVEFCVLFG GVSFEHEISI VSAIALKGVL KDRIKYFLFL DENHHFYLIE ESNMHSKYFA 

        70         80         90        100        110        120 
QIKEKKLPPL ILTHNGLLKN SFLGAKIIEL PLVINLVHGG DGEDGKLASL LEFYRIAFIG 

       130        140        150        160        170        180 
PRIEASVLSY NKYLTKLYAK DLGVKTLDYV LLNEKNRANA LDLIEFNFPF IVKPSNAGSS 

       190        200        210        220        230        240 
LGVNVVKEEK ELIYALDSAF EYSKEVLIEP FIQGVKEYNL AGCKIKKDFC FSYVEEPSKQ 

       250        260        270        280        290        300 
EFLDFKQKYL DFSRNKAPKA NLSNALEEQL KENFKKLYND LFSGAIIRCD FFVIENEVYL 

       310        320        330        340 
NEINPIPGSL ANYLFDDFKT TLENLAQSLP KTPKIQIKNS YLLQIQKNK 

« Hide

References

[1]"The complete genome sequence of Helicobacter pylori strain G27."
Baltrus D.A., Amieva M.R., Covacci A., Lowe T.M., Merrell D.S., Ottemann K.M., Stein M., Salama N.R., Guillemin K.
J. Bacteriol. 191:447-448(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G27 EMBL ACI27449.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001173 Genomic DNA. Translation: ACI27449.1.
RefSeqYP_002266315.1. NC_011333.1.

3D structure databases

ProteinModelPortalB5Z7A0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING563041.HPG27_694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI27449; ACI27449; HPG27_694.
GeneID6963583.
KEGGhpg:HPG27_694.
PATRIC20599386. VBIHelPyl113476_0748.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000102494.
KOK01921.
OMAMEFCVLF.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycHPYL563041:GC38-706-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5Z7A0_HELPG
AccessionPrimary (citable) accession number: B5Z7A0
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)