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B5Z766 (B5Z766_HELPG) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL ACI27415.1
Ordered Locus Names:HPG27_657
OrganismHelicobacter pylori (strain G27) [Complete proteome] [HAMAP] EMBL ACI27415.1
Taxonomic identifier563041 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
B5Z766 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: B12BDA171C1B0EF9

FASTA83393,171
        10         20         30         40         50         60 
MQDNSVQDNS VNETKNIVEV GIDSSIEESY LAYSMSVIIG RALPDARDGL KPVHRRILYA 

        70         80         90        100        110        120 
MHELGLTSKV AYKKSARIVG DVIGKYHPHG DNAVYDALVR MAQDFSMRLE LVDGQGNFGS 

       130        140        150        160        170        180 
IDGDNAAAMR YTEARMTKAS EEILRDIDKD TIDFVPNYDD TLKEPDILPS RLPNLLVNGA 

       190        200        210        220        230        240 
NGIAVGMATS IPPHRIDEII DALAHVLENP NAALDEILEF VKGPDFPTGG IIYGKAGIVE 

       250        260        270        280        290        300 
AYKTGRGRVK VRAKVHVEKT KNKEIIVLDE MPFQTNKAKL VEQISDLARE KQIEGISEVR 

       310        320        330        340        350        360 
DESDREGIRV VIELKRDAMS EIVLNHLYKL TTMETTFSII LLAIYNKEPK IFTLLELLRL 

       370        380        390        400        410        420 
FLNHRKTIII RRTIFELEKA KARAHILEGY LIALDNIDEI VQLIKTSQSP EAAKNALMER 

       430        440        450        460        470        480 
FTLSEIQSKA ILEMRLQRLT GLERDKIKEE YQNLLELIDD LNGILKSEDR LNGVVKTELL 

       490        500        510        520        530        540 
EVKEQFSSPR HTEIQESYEN IDIEDLIANE PMVVSMSYKG YVKRVDLKAY EKQNRGGKGK 

       550        560        570        580        590        600 
LSGSTYEDDF IENFFVANTH DILLFITNKG QLYHLKVYKI PEASRIAMGK AIVNLISLAP 

       610        620        630        640        650        660 
DEKIMATLST KDFSDERSLA FFTKNGVVKR TNLSEFGSNR SYSGIRAIVL DEGDELVSAK 

       670        680        690        700        710        720 
VVDKNVKHLL IASHLGIFIK FPLEDVREIG RTTRGVKGIR LAENDFVVGA VVISDDGNKL 

       730        740        750        760        770        780 
LSVSENGLGK QTLAEAYREQ SRGGKGIIGM RLTQKTGNLV SVISVDDENL DLMILTASAK 

       790        800        810        820        830 
MIRVSIKDIR ETGRNASGVK LINTADKVVY VNSCPKEEEP ENLETSSAQN LFE

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References

[1]"The complete genome sequence of Helicobacter pylori strain G27."
Baltrus D.A., Amieva M.R., Covacci A., Lowe T.M., Merrell D.S., Ottemann K.M., Stein M., Salama N.R., Guillemin K.
J. Bacteriol. 191:447-448(2009) [PubMed: 18952803] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001173 Genomic DNA. Translation: ACI27415.1.
RefSeqYP_002266281.1. NC_011333.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB5Z766.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6963546.
GenomeReviewsGene locus HPG27_657 in contig CP001173_GR.
KEGGhpg:HPG27_657.
PATRIC20599295. VBIHelPyl113476_0703.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG635183.
OMATSIPPHR.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB5Z766_HELPG
AccessionPrimary (citable) accession number: B5Z766
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info