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B5Z751

- B5Z751_HELPG

UniProt

B5Z751 - B5Z751_HELPG

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Protein
Bifunctional protein GlmU
Gene
glmU, HPG27_641
Organism
Helicobacter pylori (strain G27)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate.UniRule annotationSAAS annotations
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.UniRule annotationSAAS annotations

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311UDP-GlcNAc By similarityUniRule annotation
Metal bindingi116 – 1161Magnesium By similarityUniRule annotation
Binding sitei148 – 1481UDP-GlcNAc; via amide nitrogen By similarityUniRule annotation
Binding sitei162 – 1621UDP-GlcNAc By similarityUniRule annotation
Binding sitei177 – 1771UDP-GlcNAc By similarityUniRule annotation
Metal bindingi234 – 2341Magnesium By similarityUniRule annotation
Binding sitei234 – 2341UDP-GlcNAc By similarityUniRule annotation
Binding sitei321 – 3211Acetyl-CoA; amide nitrogen By similarityUniRule annotation
Binding sitei338 – 3381Acetyl-CoA By similarityUniRule annotation
Active sitei349 – 3491Proton acceptor By similarityUniRule annotation
Binding sitei352 – 3521Acetyl-CoA By similarityUniRule annotation
Binding sitei363 – 3631Acetyl-CoA By similarityUniRule annotation
Binding sitei391 – 3911Acetyl-CoA By similarityUniRule annotation
Binding sitei409 – 4091Acetyl-CoA; via amide nitrogen By similarityUniRule annotation
Binding sitei426 – 4261Acetyl-CoA By similarityUniRule annotation

GO - Molecular functioni

  1. UDP-N-acetylglucosamine diphosphorylase activity Source: UniProtKB-HAMAP
  2. glucosamine-1-phosphate N-acetyltransferase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
  2. cell morphogenesis Source: UniProtKB-HAMAP
  3. lipid A biosynthetic process Source: UniProtKB-UniPathway
  4. lipopolysaccharide biosynthetic process Source: InterPro
  5. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotations, NucleotidyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHPYL563041:GC38-653-MONOMER.
UniPathwayiUPA00113; UER00532.
UPA00113; UER00533.
UPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein GlmUUniRule annotation
Gene namesi
Name:glmUUniRule annotationImported
Ordered Locus Names:HPG27_641Imported
OrganismiHelicobacter pylori (strain G27)Imported
Taxonomic identifieri563041 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000001735: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi563041.HPG27_641.

Structurei

3D structure databases

ProteinModelPortaliB5Z751.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 236236Pyrophosphorylase By similarityUniRule annotation
Add
BLAST
Regioni17 – 204UDP-GlcNAc binding By similarityUniRule annotation
Regioni90 – 912UDP-GlcNAc binding By similarityUniRule annotation
Regioni237 – 25721Linker By similarityUniRule annotation
Add
BLAST
Regioni258 – 443186N-acetyltransferase By similarityUniRule annotation
Add
BLAST
Regioni372 – 3732Acetyl-CoA binding By similarityUniRule annotation

Sequence similaritiesi

In the C-terminal section; belongs to the transferase hexapeptide repeat family.UniRule annotation
In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.UniRule annotation

Keywords - Domaini

RepeatUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG1207.
HOGENOMiHOG000283476.
KOiK04042.
OMAiDCVTNQD.
OrthoDBiEOG6Z6FQZ.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_01631. GlmU.
InterProiIPR005882. Bifunctional_GlmU.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR025877. MobA-like_NTP_Trfase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01173. glmU. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5Z751-1 [UniParc]FASTAAdd to Basket

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MLKFPKKRIL MLSVIILAAG KGTRMRSGLP KTLHTICGEP MLFYILETAF    50
SISNDVHLVL HHQQERIKEA VLERFKGVIF HTQIVEKYSG TGGAIMQEDK 100
TPIPTKHERV LILNADMPLI TKDALTPLLE SKNNAIGLLH LADPKGYGRV 150
VLENHQVKKI VEEKDANDEE KTIKSVNAGV YFFERKFLEK YLPKLNDQNA 200
QKEYYLTDLI ALGINENETI DAIFLEEECF LGVNRQTERA KAEEIMLERL 250
RKNAMDLGVV MQLPKSIYLE KGVSFKGECV LEQGVRLIGN CLIENARIKA 300
YSVIEESQII NSSVGPFAHA RPKSVICDSH VGNFVETKNA KLQGTKAGHL 350
SYLGDCEIGK NTNVGAGVIT CNYDGKKKHQ TIIGENVFIG SDSQLVAPIT 400
IGSNVLIGSG TTITKDIPSG SLSLSRAPQI NIENGYFKFF KKP 443
Length:443
Mass (Da):49,224
Last modified:November 25, 2008 - v1
Checksum:i31C009BEBD36E708
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001173 Genomic DNA. Translation: ACI27400.1.
RefSeqiYP_002266266.1. NC_011333.1.

Genome annotation databases

EnsemblBacteriaiACI27400; ACI27400; HPG27_641.
GeneIDi6963530.
KEGGihpg:HPG27_641.
PATRICi20599261. VBIHelPyl113476_0686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001173 Genomic DNA. Translation: ACI27400.1 .
RefSeqi YP_002266266.1. NC_011333.1.

3D structure databases

ProteinModelPortali B5Z751.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 563041.HPG27_641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI27400 ; ACI27400 ; HPG27_641 .
GeneIDi 6963530.
KEGGi hpg:HPG27_641.
PATRICi 20599261. VBIHelPyl113476_0686.

Phylogenomic databases

eggNOGi COG1207.
HOGENOMi HOG000283476.
KOi K04042.
OMAi DCVTNQD.
OrthoDBi EOG6Z6FQZ.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00532 .
UPA00113 ; UER00533 .
UPA00973 .
BioCyci HPYL563041:GC38-653-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
HAMAPi MF_01631. GlmU.
InterProi IPR005882. Bifunctional_GlmU.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR025877. MobA-like_NTP_Trfase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF00132. Hexapep. 1 hit.
PF12804. NTP_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01173. glmU. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G27Imported.

Entry informationi

Entry nameiB5Z751_HELPG
AccessioniPrimary (citable) accession number: B5Z751
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotations

External Data

Dasty 3

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