Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B5Z751

- B5Z751_HELPG

UniProt

B5Z751 - B5Z751_HELPG

Protein

Bifunctional protein GlmU

Gene

glmU

Organism
Helicobacter pylori (strain G27)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.UniRule annotationSAAS annotation

    Catalytic activityi

    Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate.UniRule annotationSAAS annotation
    UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311UDP-GlcNAcUniRule annotation
    Metal bindingi116 – 1161MagnesiumUniRule annotation
    Binding sitei148 – 1481UDP-GlcNAc; via amide nitrogenUniRule annotation
    Binding sitei162 – 1621UDP-GlcNAcUniRule annotation
    Binding sitei177 – 1771UDP-GlcNAcUniRule annotation
    Metal bindingi234 – 2341MagnesiumUniRule annotation
    Binding sitei234 – 2341UDP-GlcNAcUniRule annotation
    Binding sitei321 – 3211Acetyl-CoA; amide nitrogenUniRule annotation
    Binding sitei338 – 3381Acetyl-CoAUniRule annotation
    Active sitei349 – 3491Proton acceptorUniRule annotation
    Binding sitei352 – 3521Acetyl-CoAUniRule annotation
    Binding sitei363 – 3631Acetyl-CoAUniRule annotation
    Binding sitei391 – 3911Acetyl-CoAUniRule annotation
    Binding sitei409 – 4091Acetyl-CoA; via amide nitrogenUniRule annotation
    Binding sitei426 – 4261Acetyl-CoAUniRule annotation

    GO - Molecular functioni

    1. glucosamine-1-phosphate N-acetyltransferase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. UDP-N-acetylglucosamine diphosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell morphogenesis Source: UniProtKB-HAMAP
    2. lipid A biosynthetic process Source: UniProtKB-UniPathway
    3. lipopolysaccharide biosynthetic process Source: InterPro
    4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    5. regulation of cell shape Source: UniProtKB-KW
    6. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationSAAS annotation, NucleotidyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHPYL563041:GC38-653-MONOMER.
    UniPathwayiUPA00113; UER00532.
    UPA00113; UER00533.
    UPA00973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein GlmUUniRule annotation
    Gene namesi
    Name:glmUUniRule annotationImported
    Ordered Locus Names:HPG27_641Imported
    OrganismiHelicobacter pylori (strain G27)Imported
    Taxonomic identifieri563041 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000001735: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi563041.HPG27_641.

    Structurei

    3D structure databases

    ProteinModelPortaliB5Z751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 236236PyrophosphorylaseUniRule annotationAdd
    BLAST
    Regioni17 – 204UDP-GlcNAc bindingUniRule annotation
    Regioni90 – 912UDP-GlcNAc bindingUniRule annotation
    Regioni237 – 25721LinkerUniRule annotationAdd
    BLAST
    Regioni258 – 443186N-acetyltransferaseUniRule annotationAdd
    BLAST
    Regioni372 – 3732Acetyl-CoA bindingUniRule annotation

    Sequence similaritiesi

    In the C-terminal section; belongs to the transferase hexapeptide repeat family.UniRule annotation
    In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.UniRule annotation

    Keywords - Domaini

    RepeatUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG1207.
    HOGENOMiHOG000283476.
    KOiK04042.
    OMAiDCVTNQD.
    OrthoDBiEOG6Z6FQZ.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_01631. GlmU.
    InterProiIPR005882. Bifunctional_GlmU.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR025877. MobA-like_NTP_Trfase_dom.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF00132. Hexapep. 1 hit.
    PF12804. NTP_transf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    SSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01173. glmU. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5Z751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKFPKKRIL MLSVIILAAG KGTRMRSGLP KTLHTICGEP MLFYILETAF    50
    SISNDVHLVL HHQQERIKEA VLERFKGVIF HTQIVEKYSG TGGAIMQEDK 100
    TPIPTKHERV LILNADMPLI TKDALTPLLE SKNNAIGLLH LADPKGYGRV 150
    VLENHQVKKI VEEKDANDEE KTIKSVNAGV YFFERKFLEK YLPKLNDQNA 200
    QKEYYLTDLI ALGINENETI DAIFLEEECF LGVNRQTERA KAEEIMLERL 250
    RKNAMDLGVV MQLPKSIYLE KGVSFKGECV LEQGVRLIGN CLIENARIKA 300
    YSVIEESQII NSSVGPFAHA RPKSVICDSH VGNFVETKNA KLQGTKAGHL 350
    SYLGDCEIGK NTNVGAGVIT CNYDGKKKHQ TIIGENVFIG SDSQLVAPIT 400
    IGSNVLIGSG TTITKDIPSG SLSLSRAPQI NIENGYFKFF KKP 443
    Length:443
    Mass (Da):49,224
    Last modified:November 25, 2008 - v1
    Checksum:i31C009BEBD36E708
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001173 Genomic DNA. Translation: ACI27400.1.
    RefSeqiYP_002266266.1. NC_011333.1.

    Genome annotation databases

    EnsemblBacteriaiACI27400; ACI27400; HPG27_641.
    GeneIDi6963530.
    KEGGihpg:HPG27_641.
    PATRICi20599261. VBIHelPyl113476_0686.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001173 Genomic DNA. Translation: ACI27400.1 .
    RefSeqi YP_002266266.1. NC_011333.1.

    3D structure databases

    ProteinModelPortali B5Z751.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 563041.HPG27_641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI27400 ; ACI27400 ; HPG27_641 .
    GeneIDi 6963530.
    KEGGi hpg:HPG27_641.
    PATRICi 20599261. VBIHelPyl113476_0686.

    Phylogenomic databases

    eggNOGi COG1207.
    HOGENOMi HOG000283476.
    KOi K04042.
    OMAi DCVTNQD.
    OrthoDBi EOG6Z6FQZ.

    Enzyme and pathway databases

    UniPathwayi UPA00113 ; UER00532 .
    UPA00113 ; UER00533 .
    UPA00973 .
    BioCyci HPYL563041:GC38-653-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    HAMAPi MF_01631. GlmU.
    InterProi IPR005882. Bifunctional_GlmU.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR025877. MobA-like_NTP_Trfase_dom.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF00132. Hexapep. 1 hit.
    PF12804. NTP_transf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01173. glmU. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G27Imported.

    Entry informationi

    Entry nameiB5Z751_HELPG
    AccessioniPrimary (citable) accession number: B5Z751
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 25, 2008
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported, Multifunctional enzymeUniRule annotationSAAS annotation

    External Data

    Dasty 3