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B5Z3A6

- SURE_ECO5E

UniProt

B5Z3A6 - SURE_ECO5E

Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

    Catalytic activityi

    A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    (Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Divalent metal cationUniRule annotation
    Metal bindingi9 – 91Divalent metal cationUniRule annotation
    Metal bindingi39 – 391Divalent metal cationUniRule annotation
    Metal bindingi92 – 921Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. 3'-nucleotidase activity Source: UniProtKB-HAMAP
    2. 5'-nucleotidase activity Source: UniProtKB-HAMAP
    3. exopolyphosphatase activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-HAMAP
    5. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL444450:GHOB-3982-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
    Alternative name(s):
    ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
    Nucleoside monophosphate phosphohydrolaseUniRule annotation
    Gene namesi
    Name:surEUniRule annotation
    Ordered Locus Names:ECH74115_3995
    OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)
    Taxonomic identifieri444450 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001737: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2532535'/3'-nucleotidase SurEPRO_1000092001Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi444450.ECH74115_3995.

    Structurei

    3D structure databases

    ProteinModelPortaliB5Z3A6.
    SMRiB5Z3A6. Positions 1-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SurE nucleotidase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0496.
    HOGENOMiHOG000122500.
    KOiK03787.
    OMAiQGKLEFG.
    OrthoDBiEOG68WR45.

    Family and domain databases

    Gene3Di3.40.1210.10. 1 hit.
    HAMAPiMF_00060. SurE.
    InterProiIPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view]
    PfamiPF01975. SurE. 1 hit.
    [Graphical view]
    SUPFAMiSSF64167. SSF64167. 1 hit.
    TIGRFAMsiTIGR00087. surE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5Z3A6-1 [UniParc]FASTAAdd to Basket

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    MRILLSNDDG VHAPGIQTLA KALREFADVQ VVAPDRNRSG ASNSLTLESS    50
    LRTFTFENGD IAVQMGTPTD CVYLGVNALM RPRPDIVVSG INAGPNLGDD 100
    VIYSGTVAAA MEGRHLGFPA LAVSLDGHKH YDTAAAVTCS ILRALCKEPL 150
    RTGRILNINV PDLPLDQIKG IRVTRCGTRH PADQVIPQQD PRGNTLYWIG 200
    PPGGKCDAGP GTDFAAVDEG YVSITPLHVD LTAHSAQDVV SDWLNSVGVG 250
    TQW 253
    Length:253
    Mass (Da):26,900
    Last modified:November 25, 2008 - v1
    Checksum:i33A7CD0AEE13C3DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001164 Genomic DNA. Translation: ACI37348.1.
    RefSeqiYP_002272207.1. NC_011353.1.

    Genome annotation databases

    EnsemblBacteriaiACI37348; ACI37348; ECH74115_3995.
    GeneIDi6970394.
    KEGGiecf:ECH74115_3995.
    PATRICi18368619. VBIEscCol74651_3940.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001164 Genomic DNA. Translation: ACI37348.1 .
    RefSeqi YP_002272207.1. NC_011353.1.

    3D structure databases

    ProteinModelPortali B5Z3A6.
    SMRi B5Z3A6. Positions 1-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444450.ECH74115_3995.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI37348 ; ACI37348 ; ECH74115_3995 .
    GeneIDi 6970394.
    KEGGi ecf:ECH74115_3995.
    PATRICi 18368619. VBIEscCol74651_3940.

    Phylogenomic databases

    eggNOGi COG0496.
    HOGENOMi HOG000122500.
    KOi K03787.
    OMAi QGKLEFG.
    OrthoDBi EOG68WR45.

    Enzyme and pathway databases

    BioCyci ECOL444450:GHOB-3982-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1210.10. 1 hit.
    HAMAPi MF_00060. SurE.
    InterProi IPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view ]
    Pfami PF01975. SurE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64167. SSF64167. 1 hit.
    TIGRFAMsi TIGR00087. surE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EC4115 / EHEC.

    Entry informationi

    Entry nameiSURE_ECO5E
    AccessioniPrimary (citable) accession number: B5Z3A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3