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Protein
Submitted name:

D-lactate dehydrogenase

Gene

idhA

Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Enzyme and pathway databases

BioCyciECOL444450:GHOB-1997-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
D-lactate dehydrogenaseImported
Gene namesi
Name:idhAImported
Ordered Locus Names:ECH74115_2002Imported
OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)Imported
Taxonomic identifieri444450 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001737 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi444450.ECH74115_2002.

Structurei

3D structure databases

ProteinModelPortaliB5Z0S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136695.
KOiK03778.
OMAiLMMTLNR.
OrthoDBiEOG61VZ8G.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5Z0S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAVYSTKQ YDKKYLQQVN ESFGFELEFF DFLLTEKTAK TANGCEAVCI
60 70 80 90 100
FVNDDGSRPV LEELKKHGVK YIALRCAGFN NVDLDAAKEL GLKVVRVPAY
110 120 130 140 150
DPEAVAEHAI GMMMTLNRRI HRAYQRTRDA NFSLEGLTGF TMYGKTAGVI
160 170 180 190 200
GTGKIGVAML RILKGFGMRL LAFDPYPSAA ALELGVEYVD LPTLFSESDV
210 220 230 240 250
ISLHCPLTPE NYHLLNEAAF DQMKNGVMIV NTSRGALIDS QAAIEALKNQ
260 270 280 290 300
KIGSLGMDVY ENERDLFFED KSNDVIQDDV FRRLSACHNV LFTGHQAFLT
310 320
AEALTSISQT TLQNLSNLEK GETCPNELV
Length:329
Mass (Da):36,521
Last modified:November 24, 2008 - v1
Checksum:i84E8F685F913993C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001164 Genomic DNA. Translation: ACI36029.1.
RefSeqiYP_002270410.1. NC_011353.1.

Genome annotation databases

EnsemblBacteriaiACI36029; ACI36029; ECH74115_2002.
KEGGiecf:ECH74115_2002.
PATRICi18364747. VBIEscCol74651_2052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001164 Genomic DNA. Translation: ACI36029.1.
RefSeqiYP_002270410.1. NC_011353.1.

3D structure databases

ProteinModelPortaliB5Z0S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi444450.ECH74115_2002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI36029; ACI36029; ECH74115_2002.
KEGGiecf:ECH74115_2002.
PATRICi18364747. VBIEscCol74651_2052.

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136695.
KOiK03778.
OMAiLMMTLNR.
OrthoDBiEOG61VZ8G.

Enzyme and pathway databases

BioCyciECOL444450:GHOB-1997-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EC4115 / EHECImported.

Entry informationi

Entry nameiB5Z0S0_ECO5E
AccessioniPrimary (citable) accession number: B5Z0S0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2008
Last sequence update: November 24, 2008
Last modified: March 31, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.