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B5Z044 (B5Z044_ECO5E) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862
Gene names
Name:metF EMBL ACI39839.1
Ordered Locus Names:ECH74115_5402 EMBL ACI39839.1
OrganismEscherichia coli O157:H7 (strain EC4115 / EHEC) [Complete proteome] [HAMAP] EMBL ACI39839.1
Taxonomic identifier444450 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862

Cofactor

FAD By similarity. RuleBase RU003862

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. RuleBase RU004255

Sequence similarities

Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Sequences

Sequence LengthMass (Da)Tools
B5Z044 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 1FA66221D8296676

FASTA29633,130
        10         20         30         40         50         60 
MNFFHASQRD ALNQSLAEVQ GQINVSFEFF PPRTSEMEQT LWNSIDRLSS LKPKFVSVTY 

        70         80         90        100        110        120 
GANSGERDRT HSIIKGIKDR TGLEAAPHLT CIDATPDELR TIARDYWNNG IRHIVALRGD 

       130        140        150        160        170        180 
LPPGSGKPEM YASDLVTLLK EVADFDISVA AYPEVHPEAK SAQADLLNLK RKVDAGANRA 

       190        200        210        220        230        240 
ITQFFFDVES YLRFRDRCVS AGIDVEIIPG ILPVSNFKQA KKFADMTNVR IPAWMAQMFD 

       250        260        270        280        290 
GLDDDAETRK LVGANIAMDM VKILSREGVK DFHFYTLNRA EMSYAICHTL GVRPGL

« Hide

References

[1]"Complete genome sequence of Escherichia coli O157:H7 str. EC4115."
Eppinger M., Sebastian Y., Ravel J.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EC4115 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001164 Genomic DNA. Translation: ACI39839.1.
RefSeqYP_002273464.1. NC_011353.1.

3D structure databases

ProteinModelPortalB5Z044.
SMRB5Z044. Positions 3-294.
ModBaseSearch...

Protein-protein interaction databases

STRING444450.ECH74115_5402.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI39839; ACI39839; ECH74115_5402.
GeneID6971419.
KEGGecf:ECH74115_5402.
PATRIC18371349. VBIEscCol74651_5270.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0685.
HOGENOMHOG000246232.
KOK00297.
OMASITQMFF.
ProtClustDBPRK09432.

Enzyme and pathway databases

BioCycECOL444450:GHOB-5381-MONOMER.
UniPathwayUPA00193.

Family and domain databases

InterProIPR003171. Mehydrof_redctse.
IPR004620. MTHF_reductase_bac.
[Graphical view]
PfamPF02219. MTHFR. 1 hit.
[Graphical view]
TIGRFAMsTIGR00676. fadh2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB5Z044_ECO5E
AccessionPrimary (citable) accession number: B5Z044
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: May 29, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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