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B5YWT2

- B5YWT2_ECO5E

UniProt

B5YWT2 - B5YWT2_ECO5E

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, ECH74115_1598
Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciECOL444450:GHOB-1594-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:ECH74115_1598Imported
OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)Imported
Taxonomic identifieri444450 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001737: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi444450.ECH74115_1598.

Structurei

3D structure databases

ProteinModelPortaliB5YWT2.
SMRiB5YWT2. Positions 1-416.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5YWT2-1 [UniParc]FASTAAdd to Basket

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MESKVVVPAQ GKKITLQNGK LNVPENPIIP YIEGDGIGVD VTPAMLKVVD    50
AAVEKAYKGE RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIREYRVAIK 100
GPLTTPVGGG IRSLNVALRQ ELDLYICLRP VRYYQGTPSP VKHPELTDMV 150
IFRENSEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP 200
CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA FKDWGYELAR 250
EEFGGELIDG GPWLKVKNPN TGKEIVIKDV IADAFLQQIL LRPAEYDVIA 300
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK 350
VNPGSIILSA EMMLRHMGWT EAADLIVKGM EGAINAKTVT YDFERLMEGA 400
KLLKCSEFGD AIIKNM 416
Length:416
Mass (Da):45,771
Last modified:November 25, 2008 - v1
Checksum:iECD2BFB29031F9C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001164 Genomic DNA. Translation: ACI38583.1.
RefSeqiYP_002270054.1. NC_011353.1.

Genome annotation databases

EnsemblBacteriaiACI38583; ACI38583; ECH74115_1598.
GeneIDi6968702.
KEGGiecf:ECH74115_1598.
PATRICi18363962. VBIEscCol74651_1665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001164 Genomic DNA. Translation: ACI38583.1 .
RefSeqi YP_002270054.1. NC_011353.1.

3D structure databases

ProteinModelPortali B5YWT2.
SMRi B5YWT2. Positions 1-416.
ModBasei Search...

Protein-protein interaction databases

STRINGi 444450.ECH74115_1598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI38583 ; ACI38583 ; ECH74115_1598 .
GeneIDi 6968702.
KEGGi ecf:ECH74115_1598.
PATRICi 18363962. VBIEscCol74651_1665.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci ECOL444450:GHOB-1594-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EC4115 / EHEC.

Entry informationi

Entry nameiB5YWT2_ECO5E
AccessioniPrimary (citable) accession number: B5YWT2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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