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B5YRU5

- DCYD_ECO5E

UniProt

B5YRU5 - DCYD_ECO5E

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Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-amino acid metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciECOL444450:GHOB-2687-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Ordered Locus Names:ECH74115_2693
OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)
Taxonomic identifieri444450 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001737: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328D-cysteine desulfhydrasePRO_1000136157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiB5YRU5.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi444450.ECH74115_2693.

Structurei

3D structure databases

ProteinModelPortaliB5YRU5.
SMRiB5YRU5. Positions 4-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2515.
HOGENOMiHOG000022459.
KOiK05396.
OMAiPYLVPIG.
OrthoDBiEOG6FBX0P.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

B5YRU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLHNLTRFP RLEFIGAPTP LEYLPRFSDY LGREIFIKRD DVTPMAMGGN
60 70 80 90 100
KLRKLEFLAA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE
110 120 130 140 150
NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPNAQLE ELATRVEAQG
160 170 180 190 200
FRPYVIPVGG SNALGALGYV ESALEIAQQC EGAVNISSVV VASGSAGTHA
210 220 230 240 250
GLAVGLEHLM PESELIGVTV SRSVADQLPK VVNLQQAIAK ELELTASVEI
260 270 280 290 300
LLWDDYFAPG YGVPNDEGME AVKLLARLEG ILLDPVYTGK AMAGLIDGIS
310 320
QKRFKDEGPI LFIHTGGAPA LFAYHPHV
Length:328
Mass (Da):35,181
Last modified:November 25, 2008 - v1
Checksum:i59D6392CF3EC62D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001164 Genomic DNA. Translation: ACI39001.1.
RefSeqiYP_002271033.1. NC_011353.1.

Genome annotation databases

EnsemblBacteriaiACI39001; ACI39001; ECH74115_2693.
GeneIDi6968508.
KEGGiecf:ECH74115_2693.
PATRICi18366106. VBIEscCol74651_2721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001164 Genomic DNA. Translation: ACI39001.1 .
RefSeqi YP_002271033.1. NC_011353.1.

3D structure databases

ProteinModelPortali B5YRU5.
SMRi B5YRU5. Positions 4-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444450.ECH74115_2693.

Proteomic databases

PRIDEi B5YRU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI39001 ; ACI39001 ; ECH74115_2693 .
GeneIDi 6968508.
KEGGi ecf:ECH74115_2693.
PATRICi 18366106. VBIEscCol74651_2721.

Phylogenomic databases

eggNOGi COG2515.
HOGENOMi HOG000022459.
KOi K05396.
OMAi PYLVPIG.
OrthoDBi EOG6FBX0P.

Enzyme and pathway databases

BioCyci ECOL444450:GHOB-2687-MONOMER.

Family and domain databases

HAMAPi MF_01045. D_Cys_desulfhydr.
InterProi IPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EC4115 / EHEC.

Entry informationi

Entry nameiDCYD_ECO5E
AccessioniPrimary (citable) accession number: B5YRU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3