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B5YRG5

- 6PGL_ECO5E

UniProt

B5YRG5 - 6PGL_ECO5E

Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Enzyme and pathway databases

    BioCyciECOL444450:GHOB-866-MONOMER.
    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
    Short name:
    6-P-gluconolactonaseUniRule annotation
    Gene namesi
    Name:pglUniRule annotation
    Ordered Locus Names:ECH74115_0870
    OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)
    Taxonomic identifieri444450 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001737: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3313316-phosphogluconolactonasePRO_1000148151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei287 – 2871N6-acetyllysineUniRule annotation

    Keywords - PTMi

    Acetylation

    Interactioni

    Protein-protein interaction databases

    STRINGi444450.ECH74115_0870.

    Structurei

    3D structure databases

    ProteinModelPortaliB5YRG5.
    SMRiB5YRG5. Positions 1-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cycloisomerase 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2706.
    HOGENOMiHOG000257418.
    KOiK07404.
    OMAiPMVIAPN.
    OrthoDBiEOG615VK7.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    HAMAPiMF_01605. 6P_gluconolactonase.
    InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
    IPR019405. Lactonase_7-beta_prop.
    IPR011045. N2O_reductase_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF10282. Lactonase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50974. SSF50974. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5YRG5-1 [UniParc]FASTAAdd to Basket

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    MKQTVYIASP ESQQIHVWNL NHEGALTLTQ VVDVPGQVQP MVVSPDKRYL    50
    YVGVRPEFRV LAYRIAPDDG ALTFAAESAL PGSPTHISTD HQGQFVFVGS 100
    YNAGNVSVTR LEDGLPVGVV DVVEGLDGCH SANISPDNRT LWVPALKQDR 150
    ICLFTVSDDG HLVAQDPAEV TTVEGAGPRH MVFHPNEQYA YCVNELNSSV 200
    DVWELKDPHG NIECVQTLDM MPENFSDTRW AADIHITPDG RHLYACDRTA 250
    SLITVFSVSE DGSVLSKEGF QPTETQPRGF NIDHRGKYLI AAGQKSHHIS 300
    VYEIVGEQGL LHEKGRYAVG QGPMWVVVNA H 331
    Length:331
    Mass (Da):36,391
    Last modified:November 25, 2008 - v1
    Checksum:iBC4A7F215D231BDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001164 Genomic DNA. Translation: ACI36252.1.
    RefSeqiYP_002269395.1. NC_011353.1.

    Genome annotation databases

    EnsemblBacteriaiACI36252; ACI36252; ECH74115_0870.
    GeneIDi6968682.
    KEGGiecf:ECH74115_0870.
    PATRICi18362540. VBIEscCol74651_0960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001164 Genomic DNA. Translation: ACI36252.1 .
    RefSeqi YP_002269395.1. NC_011353.1.

    3D structure databases

    ProteinModelPortali B5YRG5.
    SMRi B5YRG5. Positions 1-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444450.ECH74115_0870.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI36252 ; ACI36252 ; ECH74115_0870 .
    GeneIDi 6968682.
    KEGGi ecf:ECH74115_0870.
    PATRICi 18362540. VBIEscCol74651_0960.

    Phylogenomic databases

    eggNOGi COG2706.
    HOGENOMi HOG000257418.
    KOi K07404.
    OMAi PMVIAPN.
    OrthoDBi EOG615VK7.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .
    BioCyci ECOL444450:GHOB-866-MONOMER.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    HAMAPi MF_01605. 6P_gluconolactonase.
    InterProi IPR022528. 6-phosphogluconolactonase_YbhE.
    IPR019405. Lactonase_7-beta_prop.
    IPR011045. N2O_reductase_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF10282. Lactonase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50974. SSF50974. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EC4115 / EHEC.

    Entry informationi

    Entry namei6PGL_ECO5E
    AccessioniPrimary (citable) accession number: B5YRG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3