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Protein

Aldose 1-epimerase

Gene

galM

Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts alpha-aldose to the beta-anomer.UniRule annotation

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. aldose 1-epimerase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. galactose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Enzyme and pathway databases

BioCyciECOL444450:GHOB-855-MONOMER.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimeraseUniRule annotation (EC:5.1.3.3UniRule annotation)
Alternative name(s):
Galactose mutarotaseUniRule annotation
Gene namesi
Name:galMImported
Ordered Locus Names:ECH74115_0859Imported
OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)Imported
Taxonomic identifieri444450 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001737 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi444450.ECH74115_0859.

Structurei

3D structure databases

ProteinModelPortaliB5YRF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldose epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2017.
HOGENOMiHOG000072798.
KOiK01785.
OMAiFNLDGDQ.
OrthoDBiEOG69WFM5.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR013458. Ald_epimerase_bac.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
TIGRFAMsiTIGR02636. galM_Leloir. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5YRF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNETPALAP DGQPYRLLTL RNNAGMVVTL MDWGATLLSA RIPLSDGSVR
60 70 80 90 100
EALLGCASPE CYQDQAAFLG ASIGRYANRI ANSRYTFDGE TVTLSPSQGV
110 120 130 140 150
NQLHGGPEGF DKRRWQIVNQ NDRQVLFALS SDDGDQGFPG NLGATVQYRL
160 170 180 190 200
TDDNRISITY RATVDKPCPV NMTNHVYFNL DGKQSDVRNH KLQILADEYL
210 220 230 240 250
PVDEGGIPHD GLKSVAGTSF DFRSAKIIAS EFLADDDQRK VKGYDHAFLL
260 270 280 290 300
QAKGDGKKVA AHVWSADEKL QLKVYTTAPA LQFYSGNYLG GTPSRGTEPY
310 320 330 340
ADWQGLALES EFLPDSPNHP EWPQPDCFLH PGEEYSSLTE YQFIAE
Length:346
Mass (Da):38,186
Last modified:November 25, 2008 - v1
Checksum:i65A46187B7837597
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001164 Genomic DNA. Translation: ACI37439.1.
RefSeqiYP_002269384.1. NC_011353.1.

Genome annotation databases

EnsemblBacteriaiACI37439; ACI37439; ECH74115_0859.
KEGGiecf:ECH74115_0859.
PATRICi18362518. VBIEscCol74651_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001164 Genomic DNA. Translation: ACI37439.1.
RefSeqiYP_002269384.1. NC_011353.1.

3D structure databases

ProteinModelPortaliB5YRF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi444450.ECH74115_0859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI37439; ACI37439; ECH74115_0859.
KEGGiecf:ECH74115_0859.
PATRICi18362518. VBIEscCol74651_0949.

Phylogenomic databases

eggNOGiCOG2017.
HOGENOMiHOG000072798.
KOiK01785.
OMAiFNLDGDQ.
OrthoDBiEOG69WFM5.

Enzyme and pathway databases

UniPathwayiUPA00242.
BioCyciECOL444450:GHOB-855-MONOMER.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR013458. Ald_epimerase_bac.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
TIGRFAMsiTIGR02636. galM_Leloir. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EC4115 / EHECImported.

Entry informationi

Entry nameiB5YRF4_ECO5E
AccessioniPrimary (citable) accession number: B5YRF4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: April 1, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.