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B5YRC4 (RLMG_ECO5E) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase G
EC=2.1.1.174
Alternative name(s):
23S rRNA m2G1835 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RlmG
Gene names
Name:rlmG
Ordered Locus Names:ECH74115_4398
OrganismEscherichia coli O157:H7 (strain EC4115 / EHEC) [Complete proteome] [HAMAP]
Taxonomic identifier444450 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA By similarity. HAMAP MF_01859

Catalytic activity

S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1835) in 23S rRNA. HAMAP MF_01859

Subcellular location

Cytoplasm Potential HAMAP MF_01859.

Sequence similarities

Belongs to the methyltransferase superfamily. RlmG family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

rRNA (guanine-N2-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Ribosomal RNA large subunit methyltransferase G HAMAP MF_01859
PRO_0000366461

Sequences

Sequence LengthMass (Da)Tools
B5YRC4 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 0EA9DDBC4CA8C5EF

FASTA37842,324
        10         20         30         40         50         60 
MSHLDNGFRS LTLQRFPATD DVNPLQAWEA ADEYLLQQLD DTEIRGPVLI LNDAFGALSC 

        70         80         90        100        110        120 
ALAEHKPYSI GDSYISELAT RENLRLNGID ESSVKFLDST ADYPQQPGVV LIKVPKTLAL 

       130        140        150        160        170        180 
LEQQLRALRK VVTPQTRIIA GAKARDIHTS TLELFEKVLG PTTTTLAWKK ARLINCTFNE 

       190        200        210        220        230        240 
PPLADAPQTV SWKLEGTDWT IHNHANVFSR TGLDIGARFF MQHLPENLEG EIVDLGCGNG 

       250        260        270        280        290        300 
VIGLTLLDKN PQAKVVFVDE SPMAVASSRL NVETNMPEAL DRCEFMINNA LSGVEPFRFN 

       310        320        330        340        350        360 
AVLCNPPFHQ QHALTDNVAW EMFHHARRCL KINGELYIVA NRHLDYFHKL KKIFGNCTTI 

       370 
ATNNKFVVLK AVKLGRRR

« Hide

References

[1]"Complete genome sequence of Escherichia coli O157:H7 str. EC4115."
Eppinger M., Sebastian Y., Ravel J.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EC4115 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001164 Genomic DNA. Translation: ACI38394.1.
RefSeqYP_002272557.1. NC_011353.1.

3D structure databases

ProteinModelPortalB5YRC4.
SMRB5YRC4. Positions 27-372.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5YRC4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000030772; EBESCP00000029475; EBESCG00000029822.
GeneID6968385.
GenomeReviewsGene locus ECH74115_4398 in contig CP001164_GR.
KEGGecf:ECH74115_4398.
PATRIC18369379. VBIEscCol74651_4314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000009812.
HOGENOMHBG321931.
OMANRHLGYH.
ProtClustDBPRK15001.

Family and domain databases

HAMAPMF_01859. 23SrRNA_methyltr_G.
[Tree]
InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR007848. Small_mtfrase.
[Graphical view]
KOK11391.
PfamPF05175. MTS. 1 hit.
[Graphical view]
PIRSFPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRLMG_ECO5E
AccessionPrimary (citable) accession number: B5YRC4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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