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B5YQD4

- SPEB_ECO5E

UniProt

B5YQD4 - SPEB_ECO5E

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Protein

Agmatinase

Gene
speB, ECH74115_4239
Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine By similarity.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Manganese By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261Manganese By similarity
Metal bindingi149 – 1491Manganese By similarity
Metal bindingi151 – 1511Manganese By similarity
Metal bindingi153 – 1531Manganese By similarity
Metal bindingi230 – 2301Manganese By similarity
Metal bindingi232 – 2321Manganese By similarity

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciECOL444450:GHOB-4226-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Ordered Locus Names:ECH74115_4239
OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)
Taxonomic identifieri444450 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001737: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306AgmatinaseUniRule annotationPRO_1000145608Add
BLAST

Proteomic databases

PRIDEiB5YQD4.

Interactioni

Protein-protein interaction databases

STRINGi444450.ECH74115_4239.

Structurei

3D structure databases

ProteinModelPortaliB5YQD4.
SMRiB5YQD4. Positions 41-305.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204320.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5YQD4-1 [UniParc]FASTAAdd to Basket

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MSTLGHQYDN SLVSNAFGFL RLPMNFQPYD SDADWVITGV PFDMATSGRA    50
GGRHGPAAIR QVSTNLAWEH NRFPWNFDMR ERLNVVDCGD LVYAFGDARE 100
MSEKLQAHAE KLLAAGKRML SFGGDHFVTL PLLRAHAKHF GKMALVHFDA 150
HTDTYANGCE FDHGTMFYTA PKEGLIDPNH SVQIGIRTEF DKDNGFTVLD 200
ACQVNDRSVD DVIAQVKQIV GDMPVYLTFD IDCLDPAFAP GTGTPVIGGL 250
TSDRAIKLVR GLKDLNIVGM DVVEVAPAYD QSEITALAAA TLALEMLYIQ 300
AAKKGE 306
Length:306
Mass (Da):33,557
Last modified:November 25, 2008 - v1
Checksum:i48208BF2CF155570
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001164 Genomic DNA. Translation: ACI35219.1.
RefSeqiYP_002272416.1. NC_011353.1.

Genome annotation databases

EnsemblBacteriaiACI35219; ACI35219; ECH74115_4239.
GeneIDi6972108.
KEGGiecf:ECH74115_4239.
PATRICi18369061. VBIEscCol74651_4157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001164 Genomic DNA. Translation: ACI35219.1 .
RefSeqi YP_002272416.1. NC_011353.1.

3D structure databases

ProteinModelPortali B5YQD4.
SMRi B5YQD4. Positions 41-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444450.ECH74115_4239.

Proteomic databases

PRIDEi B5YQD4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI35219 ; ACI35219 ; ECH74115_4239 .
GeneIDi 6972108.
KEGGi ecf:ECH74115_4239.
PATRICi 18369061. VBIEscCol74651_4157.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204320.
KOi K01480.
OMAi KPDYSLY.
OrthoDBi EOG6R2GW5.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .
BioCyci ECOL444450:GHOB-4226-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
HAMAPi MF_01418. SpeB.
InterProi IPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EC4115 / EHEC.

Entry informationi

Entry nameiSPEB_ECO5E
AccessioniPrimary (citable) accession number: B5YQD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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