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B5YLE5

- PUR9_THEYD

UniProt

B5YLE5 - PUR9_THEYD

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, THEYE_A1243
Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciTYEL289376:GH9L-1236-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:THEYE_A1243
OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Taxonomic identifieri289376 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
ProteomesiUP000000718: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000096105Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi289376.THEYE_A1243.

Structurei

3D structure databases

ProteinModelPortaliB5YLE5.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B5YLE5-1 [UniParc]FASTAAdd to Basket

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MIKRALISVS DKRGLVDFAK ELDKLGVEIL STGGTAKTLR DSGIKVIDVS    50
QYTGFPEIMD GRVKTLHPLI HGGILARRDN KEDIEAMERL GIKPIDMVVV 100
NLYPFESVAK KHLSQILQPS DLNLQAFLEE AIENIDIGGP TLLRASAKNY 150
KDVIVIVDPD DYSSIIEDIK KGSVSIEKKF ELAKKVFSHT ARYDALIADY 200
FEKISPSGFK KDWTLPLKMT RTLRYGENPH QKAALYALNE SPSLIDADVL 250
QGKEMSFNNY LDTHSAVLLA TEFSEPVCVI VKHNNPCGVA IGENIHTAYK 300
KAFECDPVSA FGGIIAFNRV VDKETASEII NTFYEVIVAP DFDKDALEVF 350
ETKKNLRLLR FPSLSDKIQP SGFDLKRILG GFIVQEWDKV DNEFSQAKVV 400
TKRQPTDEEW KALKFAWKVC KHIKSNAVVY AKEDRTVGLG IGQTSRVFSA 450
KIGAMHALSS LKGTVVASDG FFPFRDNIDV LAQNGVTSII QPGGSVRDQE 500
VIDAANQYNI AMVFTGIRHF RH 522
Length:522
Mass (Da):58,100
Last modified:November 25, 2008 - v1
Checksum:i83323A65C8570910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001147 Genomic DNA. Translation: ACI21021.1.
RefSeqiYP_002249060.1. NC_011296.1.

Genome annotation databases

EnsemblBacteriaiACI21021; ACI21021; THEYE_A1243.
GeneIDi6943286.
KEGGitye:THEYE_A1243.
PATRICi23909503. VBITheYel104483_1215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001147 Genomic DNA. Translation: ACI21021.1 .
RefSeqi YP_002249060.1. NC_011296.1.

3D structure databases

ProteinModelPortali B5YLE5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 289376.THEYE_A1243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI21021 ; ACI21021 ; THEYE_A1243 .
GeneIDi 6943286.
KEGGi tye:THEYE_A1243.
PATRICi 23909503. VBITheYel104483_1215.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci TYEL289376:GH9L-1236-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51303 / DSM 11347 / YP87.

Entry informationi

Entry nameiPUR9_THEYD
AccessioniPrimary (citable) accession number: B5YLE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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