B5YJY3 (MUTS_THEYD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutS

Gene names

Name:	mutS
Ordered Locus Names:	THEYE_A0706

Organism

Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) [Reference proteome] [HAMAP]

Taxonomic identifier

289376 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Nitrospirae › Nitrospira › Nitrospirales › Nitrospiraceae › Thermodesulfovibrio › Thermodesulfovibrio yellowstonii

Protein attributes

Sequence length	852 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096
Sequence similarities	Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP damaged DNA binding Inferred from electronic annotation. Source: HAMAP mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 852	852	DNA mismatch repair protein MutS HAMAP-Rule MF_00096		PRO_1000093652
Regions
	Nucleotide binding	615 – 622	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B5YJY3 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: D3368DA92FB2B990	FASTA	852	97,306
	10 20 30 40 50 60 MEVSQEELTP LMRQYLRVKE QYKDAIVFFR LGDFYEMFGE DAVIASKILG ITLTSRDKSK 70 80 90 100 110 120 EKAIPMCGIP YFSADSYIEK LLREGYKVAI CEQIGDPKTS KGIVEREVIK VLTPGTYLPE 130 140 150 160 170 180 GVRENIYIMS IYPSKGKIGI ALADITTGQF FLYETDKNIT DEIERFEPKE ILIPASFEDS 190 200 210 220 230 240 LKFEISSYNK TFIEDWKFDY LLAYKTLLEH FKVASLKSYG AEEFSNAISA GGALLKYLEE 250 260 270 280 290 300 NKQQTEFKGI KILNLSEFML LDASTKKNLE IFVSLDGSRE GSLIWVLDET LTPMGARFLK 310 320 330 340 350 360 NTLSCPLLNI SEIEKRFDGI EAFCGDYLLR EKLEKILKDF PDIERIALKI KGKSINPKEL 370 380 390 400 410 420 NSLKNALKRI PELREVLRNK TEILNSLYNS LYELNELVTK IENALTENPP PVITEGGIFR 430 440 450 460 470 480 DGYNSTIDEL RALRTESKKY ILNMEAEERK KTGINSLKIG YNRVFGYYIE VTKPNLHLVP 490 500 510 520 530 540 SHYIRKQTLA NAERFITEEL KELELKIMSA EEKLKILEQE LFIELVNSIL PFTDKILNNG 550 560 570 580 590 600 ETIGFIDFLL SLAKVASKYN YVRPEINEED IIEIKDGRHP VIERLIQLGK LYEGRFIPND 610 620 630 640 650 660 LLIGPADQRI IILTGPNMAG KSTYMRQNAL IVLMAQIGSF VPAKYAKIGI VDRIFTRIGA 670 680 690 700 710 720 SDYLAKGQST FMVEMIETAN ILNNATPKSF IILDEVGRGT STFDGISIAW SVVEYIAEKI 730 740 750 760 770 780 KARTLFATHY HELTDLAFNL DCIKNFTVVV KEWGDEIIFL RKIQEGGADK SYGIQVARLA 790 800 810 820 830 840 GLPLEILNRA REILHRLEKK EFQVFPIRAR QLDLFFQGDP IKAELSKIDI DSLNPQKALK 850 KLKELKEMLK ND

References

[1]

"The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87." Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51303 / DSM 11347 / YP87.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001147 Genomic DNA. Translation: ACI20467.1.
RefSeq	YP_002248548.1. NC_011296.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	289376.THEYE_A0706.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACI20467; ACI20467; THEYE_A0706.
GeneID	6942606.
KEGG	tye:THEYE_A0706.
PATRIC	23908433. VBITheYel104483_0698.
Phylogenomic databases
eggNOG	COG0249.
HOGENOM	HOG000221406.
KO	K03555.
OMA	ELDEWRM.
Family and domain databases
Gene3D	3.30.420.110. 1 hit. 3.40.1170.10. 1 hit.
HAMAP	MF_00096. MutS.
InterPro	IPR005748. DNA_mismatch_repair_MutS-1. IPR007695. DNA_mismatch_repair_MutS-lik_N. IPR000432. DNA_mismatch_repair_MutS_C. IPR007861. DNA_mismatch_repair_MutS_clamp. IPR007696. DNA_mismatch_repair_MutS_core. IPR016151. DNA_mismatch_repair_MutS_N. IPR007860. DNA_mmatch_repair_MutS_con_dom. [Graphical view]
PANTHER	PTHR11361:SF34. PTHR11361:SF34. 1 hit.
Pfam	PF01624. MutS_I. 1 hit. PF05188. MutS_II. 1 hit. PF05192. MutS_III. 1 hit. PF05190. MutS_IV. 1 hit. PF00488. MutS_V. 1 hit. [Graphical view]
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF53150. DNA_mismatch_repair_MutS_connt. 1 hit. SSF55271. DNA_mismatch_repair_MutS_N. 1 hit. SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMs	TIGR01070. mutS1. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTS_THEYD

Accession

Primary (citable) accession number: B5YJY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program