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B5YJE1

- FTHS_THEYD

UniProt

B5YJE1 - FTHS_THEYD

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 818ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTYEL289376:GH9L-511-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:THEYE_A0513
    OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
    Taxonomic identifieri289376 [NCBI]
    Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
    ProteomesiUP000000718: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589Formate--tetrahydrofolate ligasePRO_1000146709Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi289376.THEYE_A0513.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiQLRYIND.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5YJE1-1 [UniParc]FASTAAdd to Basket

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    MLPEPVSCPD WLIAQEAEKR MKSIFQLAEE LDIKKEELIP YGSYIAKIDY    50
    RKLYSRIKNN PNGKYIIVTA ITPTPFGEGK STTTIGLTQG LGKRGKKVSC 100
    AIRQPSAGPL MNIKGSAAGG GLSQCIPRTE FSLGFTGDIN AVMNAHNLAM 150
    VALTSRMLHE ANYSDEILKK RGLRRLDIDP KRVQMGWVID FCVQALRKIV 200
    IGLGGKKDGI TMESRFDIAT SSELMAILSL VKDLKELKKR ISSIVVAYSK 250
    TGNPITTEDL EVSGAMSALM LPAFNPNLIQ TIEGQPVFVH AAPFANIAIG 300
    QSSIIADMVG LKLNEYHVTE CGFGADIGFE KFWNIKCRTS GLKPDVAVLV 350
    ATLRALKYHG ADKDSPKIIP GNPLPKEYIE KNMQWLERGM KNLFHHIKII 400
    KKSGLSIVVC INKFQSDTHE ELDFVRKFCE EMGIPVAISE HWQKGGQGAL 450
    ELADFVIDAC KNNSNFNFLY ENSLPHISRI ELIAREIYGA DSVEFSPLAL 500
    EKLQSINSKK EFSDFAICIA KTHLSLSDNP LLRGVPEGWQ LFIRDILVFY 550
    GAKLIVPVAG EISLMPGTAS TPNFRTIDVD LQTGKVTGI 589
    Length:589
    Mass (Da):64,990
    Last modified:November 25, 2008 - v1
    Checksum:iC8FACC5770FB32D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001147 Genomic DNA. Translation: ACI21937.1.
    RefSeqiYP_002248356.1. NC_011296.1.

    Genome annotation databases

    EnsemblBacteriaiACI21937; ACI21937; THEYE_A0513.
    GeneIDi6941446.
    KEGGitye:THEYE_A0513.
    PATRICi23908049. VBITheYel104483_0507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001147 Genomic DNA. Translation: ACI21937.1 .
    RefSeqi YP_002248356.1. NC_011296.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 289376.THEYE_A0513.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI21937 ; ACI21937 ; THEYE_A0513 .
    GeneIDi 6941446.
    KEGGi tye:THEYE_A0513.
    PATRICi 23908049. VBITheYel104483_0507.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi QLRYIND.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TYEL289376:GH9L-511-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87."
      Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51303 / DSM 11347 / YP87.

    Entry informationi

    Entry nameiFTHS_THEYD
    AccessioniPrimary (citable) accession number: B5YJE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3