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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 81ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:THEYE_A0513
OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Taxonomic identifieri289376 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
Proteomesi
  • UP000000718 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001467091 – 589Formate--tetrahydrofolate ligaseAdd BLAST589

Interactioni

Protein-protein interaction databases

STRINGi289376.THEYE_A0513.

Structurei

3D structure databases

SMRiB5YJE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
InParanoidiB5YJE1.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.

Sequencei

Sequence statusi: Complete.

B5YJE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPEPVSCPD WLIAQEAEKR MKSIFQLAEE LDIKKEELIP YGSYIAKIDY
60 70 80 90 100
RKLYSRIKNN PNGKYIIVTA ITPTPFGEGK STTTIGLTQG LGKRGKKVSC
110 120 130 140 150
AIRQPSAGPL MNIKGSAAGG GLSQCIPRTE FSLGFTGDIN AVMNAHNLAM
160 170 180 190 200
VALTSRMLHE ANYSDEILKK RGLRRLDIDP KRVQMGWVID FCVQALRKIV
210 220 230 240 250
IGLGGKKDGI TMESRFDIAT SSELMAILSL VKDLKELKKR ISSIVVAYSK
260 270 280 290 300
TGNPITTEDL EVSGAMSALM LPAFNPNLIQ TIEGQPVFVH AAPFANIAIG
310 320 330 340 350
QSSIIADMVG LKLNEYHVTE CGFGADIGFE KFWNIKCRTS GLKPDVAVLV
360 370 380 390 400
ATLRALKYHG ADKDSPKIIP GNPLPKEYIE KNMQWLERGM KNLFHHIKII
410 420 430 440 450
KKSGLSIVVC INKFQSDTHE ELDFVRKFCE EMGIPVAISE HWQKGGQGAL
460 470 480 490 500
ELADFVIDAC KNNSNFNFLY ENSLPHISRI ELIAREIYGA DSVEFSPLAL
510 520 530 540 550
EKLQSINSKK EFSDFAICIA KTHLSLSDNP LLRGVPEGWQ LFIRDILVFY
560 570 580
GAKLIVPVAG EISLMPGTAS TPNFRTIDVD LQTGKVTGI
Length:589
Mass (Da):64,990
Last modified:November 25, 2008 - v1
Checksum:iC8FACC5770FB32D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001147 Genomic DNA. Translation: ACI21937.1.
RefSeqiWP_012546634.1. NC_011296.1.
YP_002248356.1. NC_011296.1.

Genome annotation databases

EnsemblBacteriaiACI21937; ACI21937; THEYE_A0513.
GeneIDi6941446.
KEGGitye:THEYE_A0513.
PATRICifig|289376.4.peg.507.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS_THEYD
AccessioniPrimary (citable) accession number: B5YJE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: June 7, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families