SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B5YJE1

- FTHS_THEYD

UniProt

B5YJE1 - FTHS_THEYD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene
fhs, THEYE_A0513
Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 818ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTYEL289376:GH9L-511-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:THEYE_A0513
OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Taxonomic identifieri289376 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
ProteomesiUP000000718: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000146709Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi289376.THEYE_A0513.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5YJE1-1 [UniParc]FASTAAdd to Basket

« Hide

MLPEPVSCPD WLIAQEAEKR MKSIFQLAEE LDIKKEELIP YGSYIAKIDY    50
RKLYSRIKNN PNGKYIIVTA ITPTPFGEGK STTTIGLTQG LGKRGKKVSC 100
AIRQPSAGPL MNIKGSAAGG GLSQCIPRTE FSLGFTGDIN AVMNAHNLAM 150
VALTSRMLHE ANYSDEILKK RGLRRLDIDP KRVQMGWVID FCVQALRKIV 200
IGLGGKKDGI TMESRFDIAT SSELMAILSL VKDLKELKKR ISSIVVAYSK 250
TGNPITTEDL EVSGAMSALM LPAFNPNLIQ TIEGQPVFVH AAPFANIAIG 300
QSSIIADMVG LKLNEYHVTE CGFGADIGFE KFWNIKCRTS GLKPDVAVLV 350
ATLRALKYHG ADKDSPKIIP GNPLPKEYIE KNMQWLERGM KNLFHHIKII 400
KKSGLSIVVC INKFQSDTHE ELDFVRKFCE EMGIPVAISE HWQKGGQGAL 450
ELADFVIDAC KNNSNFNFLY ENSLPHISRI ELIAREIYGA DSVEFSPLAL 500
EKLQSINSKK EFSDFAICIA KTHLSLSDNP LLRGVPEGWQ LFIRDILVFY 550
GAKLIVPVAG EISLMPGTAS TPNFRTIDVD LQTGKVTGI 589
Length:589
Mass (Da):64,990
Last modified:November 25, 2008 - v1
Checksum:iC8FACC5770FB32D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001147 Genomic DNA. Translation: ACI21937.1.
RefSeqiYP_002248356.1. NC_011296.1.

Genome annotation databases

EnsemblBacteriaiACI21937; ACI21937; THEYE_A0513.
GeneIDi6941446.
KEGGitye:THEYE_A0513.
PATRICi23908049. VBITheYel104483_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001147 Genomic DNA. Translation: ACI21937.1 .
RefSeqi YP_002248356.1. NC_011296.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 289376.THEYE_A0513.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI21937 ; ACI21937 ; THEYE_A0513 .
GeneIDi 6941446.
KEGGi tye:THEYE_A0513.
PATRICi 23908049. VBITheYel104483_0507.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TYEL289376:GH9L-511-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51303 / DSM 11347 / YP87.

Entry informationi

Entry nameiFTHS_THEYD
AccessioniPrimary (citable) accession number: B5YJE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi