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B5YJE1 (FTHS_THEYD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:THEYE_A0513
OrganismThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) [Reference proteome] [HAMAP]
Taxonomic identifier289376 [NCBI]
Taxonomic lineageBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146709

Regions

Nucleotide binding74 – 818ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B5YJE1 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: C8FACC5770FB32D5

FASTA58964,990
        10         20         30         40         50         60 
MLPEPVSCPD WLIAQEAEKR MKSIFQLAEE LDIKKEELIP YGSYIAKIDY RKLYSRIKNN 

        70         80         90        100        110        120 
PNGKYIIVTA ITPTPFGEGK STTTIGLTQG LGKRGKKVSC AIRQPSAGPL MNIKGSAAGG 

       130        140        150        160        170        180 
GLSQCIPRTE FSLGFTGDIN AVMNAHNLAM VALTSRMLHE ANYSDEILKK RGLRRLDIDP 

       190        200        210        220        230        240 
KRVQMGWVID FCVQALRKIV IGLGGKKDGI TMESRFDIAT SSELMAILSL VKDLKELKKR 

       250        260        270        280        290        300 
ISSIVVAYSK TGNPITTEDL EVSGAMSALM LPAFNPNLIQ TIEGQPVFVH AAPFANIAIG 

       310        320        330        340        350        360 
QSSIIADMVG LKLNEYHVTE CGFGADIGFE KFWNIKCRTS GLKPDVAVLV ATLRALKYHG 

       370        380        390        400        410        420 
ADKDSPKIIP GNPLPKEYIE KNMQWLERGM KNLFHHIKII KKSGLSIVVC INKFQSDTHE 

       430        440        450        460        470        480 
ELDFVRKFCE EMGIPVAISE HWQKGGQGAL ELADFVIDAC KNNSNFNFLY ENSLPHISRI 

       490        500        510        520        530        540 
ELIAREIYGA DSVEFSPLAL EKLQSINSKK EFSDFAICIA KTHLSLSDNP LLRGVPEGWQ 

       550        560        570        580 
LFIRDILVFY GAKLIVPVAG EISLMPGTAS TPNFRTIDVD LQTGKVTGI 

« Hide

References

[1]"The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51303 / DSM 11347 / YP87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001147 Genomic DNA. Translation: ACI21937.1.
RefSeqYP_002248356.1. NC_011296.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING289376.THEYE_A0513.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI21937; ACI21937; THEYE_A0513.
GeneID6941446.
KEGGtye:THEYE_A0513.
PATRIC23908049. VBITheYel104483_0507.

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13507.

Enzyme and pathway databases

BioCycTYEL289376:GH9L-511-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THEYD
AccessionPrimary (citable) accession number: B5YJE1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways