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B5YJD3

- METE_THEYD

UniProt

B5YJD3 - METE_THEYD

Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

    Catalytic activityi

    5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi631 – 6311ZincUniRule annotation
    Metal bindingi633 – 6331ZincUniRule annotation
    Metal bindingi716 – 7161ZincUniRule annotation

    GO - Molecular functioni

    1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. methionine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciTYEL289376:GH9L-502-MONOMER.
    UniPathwayiUPA00051; UER00082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
    Alternative name(s):
    Cobalamin-independent methionine synthaseUniRule annotation
    Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
    Gene namesi
    Name:metEUniRule annotation
    Ordered Locus Names:THEYE_A0504
    OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
    Taxonomic identifieri289376 [NCBI]
    Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
    ProteomesiUP000000718: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7457455-methyltetrahydropteroyltriglutamate--homocysteine methyltransferasePRO_1000097850Add
    BLAST

    Proteomic databases

    PRIDEiB5YJD3.

    Interactioni

    Protein-protein interaction databases

    STRINGi289376.THEYE_A0504.

    Structurei

    3D structure databases

    ProteinModelPortaliB5YJD3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0620.
    HOGENOMiHOG000246221.
    KOiK00549.
    OMAiYPRIGPD.
    OrthoDBiEOG6FFS3G.

    Family and domain databases

    HAMAPiMF_00172. Meth_synth.
    InterProiIPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view]
    PfamiPF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5YJD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKTTVFGY PRIGPKRELK KALEDYWNWK ISKVELLETA NSLIIQNAKV    50
    IQSSGVDLIP SNEFSLYDFI LDHSVMFNAV PKRFNRISDP LDRYFAMARG 100
    TQELPALEMT KWFNTNYHYI VPEIEDEEFE LMENKPLREF ALLRDSLSVK 150
    TKPVIVGPFT YLKSAKLNMD RVERLSEKIL PAYKKLLIKL DAAGVEEIQI 200
    DEPAMVMDME EREIELLTGL YRELTKGLTL KVYIQTYYEA VSAYEKLVFS 250
    LSVHGFGFDL VDGKENLENI LTLGFPSDKV LIAGVVSGRD PWRTDFTVVM 300
    SMLERLFRVT DKIMLSNSSP LIHLPITVEA ERGHIQEDIL NMLSFANERL 350
    EELTILKRAI NDGAALPARK SIVHEIFSKA EVRSKISSID EKAILRKPEF 400
    QERYRMQMDS LKLPLFPTTT IGSFPQTKEV RKFRADYKNG KITEEEYKKF 450
    IFQEIEKAVK IQEELDIDVL VHGEFERTDM VEFFAEKLKG FAITKNGWVQ 500
    SYGSRCVRPP VIYGDVWRDK ALTVEETLYA QSLTPRPVKG IMTGAVTILQ 550
    WSYPRKDISR REIAYQIALA LKEEVLELEK RGIKIIQIDE PAFREGLPLK 600
    RNKQDEYFDW TINSFRLTTA DVSPFTQIHT HMCYSDFNEI IDRIYALDAD 650
    VISIEASRSK GEILSAFENF RYDHGIGLGV YDIHSPRVPS VEEMIEIIER 700
    SVSLIDKSLF WINPDCGLKT RGWQETVASL KNMVLAAKAM RKREV 745
    Length:745
    Mass (Da):85,984
    Last modified:November 25, 2008 - v1
    Checksum:iC4C8F5367B4EF5BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001147 Genomic DNA. Translation: ACI21086.1.
    RefSeqiWP_012545812.1. NC_011296.1.
    YP_002248348.1. NC_011296.1.

    Genome annotation databases

    EnsemblBacteriaiACI21086; ACI21086; THEYE_A0504.
    GeneIDi6943070.
    KEGGitye:THEYE_A0504.
    PATRICi23908031. VBITheYel104483_0499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001147 Genomic DNA. Translation: ACI21086.1 .
    RefSeqi WP_012545812.1. NC_011296.1.
    YP_002248348.1. NC_011296.1.

    3D structure databases

    ProteinModelPortali B5YJD3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 289376.THEYE_A0504.

    Proteomic databases

    PRIDEi B5YJD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI21086 ; ACI21086 ; THEYE_A0504 .
    GeneIDi 6943070.
    KEGGi tye:THEYE_A0504.
    PATRICi 23908031. VBITheYel104483_0499.

    Phylogenomic databases

    eggNOGi COG0620.
    HOGENOMi HOG000246221.
    KOi K00549.
    OMAi YPRIGPD.
    OrthoDBi EOG6FFS3G.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00082 .
    BioCyci TYEL289376:GH9L-502-MONOMER.

    Family and domain databases

    HAMAPi MF_00172. Meth_synth.
    InterProi IPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view ]
    Pfami PF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87."
      Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51303 / DSM 11347 / YP87.

    Entry informationi

    Entry nameiMETE_THEYD
    AccessioniPrimary (citable) accession number: B5YJD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3