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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi631ZincUniRule annotation1
Metal bindingi633ZincUniRule annotation1
Metal bindingi716ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciTYEL289376:G1GCQ-503-MONOMER
UniPathwayiUPA00051; UER00082

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:THEYE_A0504
OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Taxonomic identifieri289376 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
Proteomesi
  • UP000000718 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000978501 – 7455-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseAdd BLAST745

Proteomic databases

PRIDEiB5YJD3

Interactioni

Protein-protein interaction databases

STRINGi289376.THEYE_A0504

Structurei

3D structure databases

ProteinModelPortaliB5YJD3
SMRiB5YJD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107QYE Bacteria
COG0620 LUCA
HOGENOMiHOG000246221
InParanoidiB5YJD3
KOiK00549
OMAiGRNIWKN
OrthoDBiPOG091H0282

Family and domain databases

Gene3Di3.20.20.210, 4 hits
HAMAPiMF_00172 Meth_synth, 1 hit
InterProiView protein in InterPro
IPR013215 Cbl-indep_Met_Synth_N
IPR006276 Cobalamin-indep_Met_synthase
IPR002629 Met_Synth_C/arc
IPR038071 UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267 Meth_synt_1, 1 hit
PF01717 Meth_synt_2, 1 hit
PIRSFiPIRSF000382 MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726 SSF51726, 2 hits
TIGRFAMsiTIGR01371 met_syn_B12ind, 1 hit

Sequencei

Sequence statusi: Complete.

B5YJD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKTTVFGY PRIGPKRELK KALEDYWNWK ISKVELLETA NSLIIQNAKV
60 70 80 90 100
IQSSGVDLIP SNEFSLYDFI LDHSVMFNAV PKRFNRISDP LDRYFAMARG
110 120 130 140 150
TQELPALEMT KWFNTNYHYI VPEIEDEEFE LMENKPLREF ALLRDSLSVK
160 170 180 190 200
TKPVIVGPFT YLKSAKLNMD RVERLSEKIL PAYKKLLIKL DAAGVEEIQI
210 220 230 240 250
DEPAMVMDME EREIELLTGL YRELTKGLTL KVYIQTYYEA VSAYEKLVFS
260 270 280 290 300
LSVHGFGFDL VDGKENLENI LTLGFPSDKV LIAGVVSGRD PWRTDFTVVM
310 320 330 340 350
SMLERLFRVT DKIMLSNSSP LIHLPITVEA ERGHIQEDIL NMLSFANERL
360 370 380 390 400
EELTILKRAI NDGAALPARK SIVHEIFSKA EVRSKISSID EKAILRKPEF
410 420 430 440 450
QERYRMQMDS LKLPLFPTTT IGSFPQTKEV RKFRADYKNG KITEEEYKKF
460 470 480 490 500
IFQEIEKAVK IQEELDIDVL VHGEFERTDM VEFFAEKLKG FAITKNGWVQ
510 520 530 540 550
SYGSRCVRPP VIYGDVWRDK ALTVEETLYA QSLTPRPVKG IMTGAVTILQ
560 570 580 590 600
WSYPRKDISR REIAYQIALA LKEEVLELEK RGIKIIQIDE PAFREGLPLK
610 620 630 640 650
RNKQDEYFDW TINSFRLTTA DVSPFTQIHT HMCYSDFNEI IDRIYALDAD
660 670 680 690 700
VISIEASRSK GEILSAFENF RYDHGIGLGV YDIHSPRVPS VEEMIEIIER
710 720 730 740
SVSLIDKSLF WINPDCGLKT RGWQETVASL KNMVLAAKAM RKREV
Length:745
Mass (Da):85,984
Last modified:November 25, 2008 - v1
Checksum:iC4C8F5367B4EF5BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001147 Genomic DNA Translation: ACI21086.1
RefSeqiWP_012545812.1, NC_011296.1
YP_002248348.1, NC_011296.1

Genome annotation databases

EnsemblBacteriaiACI21086; ACI21086; THEYE_A0504
GeneIDi6943070
KEGGitye:THEYE_A0504
PATRICifig|289376.4.peg.499

Similar proteinsi

Entry informationi

Entry nameiMETE_THEYD
AccessioniPrimary (citable) accession number: B5YJD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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