SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B5YJD3

- METE_THEYD

UniProt

B5YJD3 - METE_THEYD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene
metE, THEYE_A0504
Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi631 – 6311Zinc By similarity
Metal bindingi633 – 6331Zinc By similarity
Metal bindingi716 – 7161Zinc By similarity

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciTYEL289376:GH9L-502-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC:2.1.1.14)
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene namesi
Name:metE
Ordered Locus Names:THEYE_A0504
OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Taxonomic identifieri289376 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
ProteomesiUP000000718: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7457455-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotationPRO_1000097850Add
BLAST

Proteomic databases

PRIDEiB5YJD3.

Interactioni

Protein-protein interaction databases

STRINGi289376.THEYE_A0504.

Structurei

3D structure databases

ProteinModelPortaliB5YJD3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000246221.
KOiK00549.
OMAiYPRIGPD.
OrthoDBiEOG6FFS3G.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

B5YJD3-1 [UniParc]FASTAAdd to Basket

« Hide

MKIKTTVFGY PRIGPKRELK KALEDYWNWK ISKVELLETA NSLIIQNAKV    50
IQSSGVDLIP SNEFSLYDFI LDHSVMFNAV PKRFNRISDP LDRYFAMARG 100
TQELPALEMT KWFNTNYHYI VPEIEDEEFE LMENKPLREF ALLRDSLSVK 150
TKPVIVGPFT YLKSAKLNMD RVERLSEKIL PAYKKLLIKL DAAGVEEIQI 200
DEPAMVMDME EREIELLTGL YRELTKGLTL KVYIQTYYEA VSAYEKLVFS 250
LSVHGFGFDL VDGKENLENI LTLGFPSDKV LIAGVVSGRD PWRTDFTVVM 300
SMLERLFRVT DKIMLSNSSP LIHLPITVEA ERGHIQEDIL NMLSFANERL 350
EELTILKRAI NDGAALPARK SIVHEIFSKA EVRSKISSID EKAILRKPEF 400
QERYRMQMDS LKLPLFPTTT IGSFPQTKEV RKFRADYKNG KITEEEYKKF 450
IFQEIEKAVK IQEELDIDVL VHGEFERTDM VEFFAEKLKG FAITKNGWVQ 500
SYGSRCVRPP VIYGDVWRDK ALTVEETLYA QSLTPRPVKG IMTGAVTILQ 550
WSYPRKDISR REIAYQIALA LKEEVLELEK RGIKIIQIDE PAFREGLPLK 600
RNKQDEYFDW TINSFRLTTA DVSPFTQIHT HMCYSDFNEI IDRIYALDAD 650
VISIEASRSK GEILSAFENF RYDHGIGLGV YDIHSPRVPS VEEMIEIIER 700
SVSLIDKSLF WINPDCGLKT RGWQETVASL KNMVLAAKAM RKREV 745
Length:745
Mass (Da):85,984
Last modified:November 25, 2008 - v1
Checksum:iC4C8F5367B4EF5BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001147 Genomic DNA. Translation: ACI21086.1.
RefSeqiWP_012545812.1. NC_011296.1.
YP_002248348.1. NC_011296.1.

Genome annotation databases

EnsemblBacteriaiACI21086; ACI21086; THEYE_A0504.
GeneIDi6943070.
KEGGitye:THEYE_A0504.
PATRICi23908031. VBITheYel104483_0499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001147 Genomic DNA. Translation: ACI21086.1 .
RefSeqi WP_012545812.1. NC_011296.1.
YP_002248348.1. NC_011296.1.

3D structure databases

ProteinModelPortali B5YJD3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 289376.THEYE_A0504.

Proteomic databases

PRIDEi B5YJD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI21086 ; ACI21086 ; THEYE_A0504 .
GeneIDi 6943070.
KEGGi tye:THEYE_A0504.
PATRICi 23908031. VBITheYel104483_0499.

Phylogenomic databases

eggNOGi COG0620.
HOGENOMi HOG000246221.
KOi K00549.
OMAi YPRIGPD.
OrthoDBi EOG6FFS3G.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci TYEL289376:GH9L-502-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51303 / DSM 11347 / YP87.

Entry informationi

Entry nameiMETE_THEYD
AccessioniPrimary (citable) accession number: B5YJD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi