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B5YID8 (UPPP_THEYD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:THEYE_A1979
OrganismThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) [Reference proteome] [HAMAP]
Taxonomic identifier289376 [NCBI]
Taxonomic lineageBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197416

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane106 – 12621Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane235 – 25521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B5YID8 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 13BDBB602DCCA34B

FASTA25728,539
        10         20         30         40         50         60 
MDELFKAIIL GIIQGITEFL PISSTAHLVI TPWIFGWSGI VNSLSFDIAV HVGTLISLLY 

        70         80         90        100        110        120 
CFWKDWINIF FRERKMLLFI IIGTIPAGIA GIAFHDLIES ALRHPLIIVV TLILVGFLML 

       130        140        150        160        170        180 
YAEKVGKKLI RSITLSDAVV IGTAQAIALI PGVSRSGITI TAGLFKGLDR AYAAKFSFLL 

       190        200        210        220        230        240 
STPAIAGAAM LDFYKSIKIG HSHDYSLFII GVISAAITGI IAIKFLLSFL QKYPLNLFIY 

       250 
YRWFLAVVIF LLYFFRN 

« Hide

References

[1]"The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51303 / DSM 11347 / YP87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001147 Genomic DNA. Translation: ACI22011.1.
RefSeqYP_002249769.1. NC_011296.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING289376.THEYE_A1979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI22011; ACI22011; THEYE_A1979.
GeneID6942160.
KEGGtye:THEYE_A1979.
PATRIC23910985. VBITheYel104483_1934.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycTYEL289376:GH9L-1968-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_THEYD
AccessionPrimary (citable) accession number: B5YID8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families