B5YID8 (UPPP_THEYD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	THEYE_A1979

Organism

Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) [Reference proteome] [HAMAP]

Taxonomic identifier

289376 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Nitrospirae › Nitrospira › Nitrospirales › Nitrospiraceae › Thermodesulfovibrio › Thermodesulfovibrio yellowstonii

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000197416
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	106 – 126	21	Helical; Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Transmembrane	207 – 227	21	Helical; Potential
	Transmembrane	235 – 255	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B5YID8 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 13BDBB602DCCA34B	FASTA	257	28,539
	10 20 30 40 50 60 MDELFKAIIL GIIQGITEFL PISSTAHLVI TPWIFGWSGI VNSLSFDIAV HVGTLISLLY 70 80 90 100 110 120 CFWKDWINIF FRERKMLLFI IIGTIPAGIA GIAFHDLIES ALRHPLIIVV TLILVGFLML 130 140 150 160 170 180 YAEKVGKKLI RSITLSDAVV IGTAQAIALI PGVSRSGITI TAGLFKGLDR AYAAKFSFLL 190 200 210 220 230 240 STPAIAGAAM LDFYKSIKIG HSHDYSLFII GVISAAITGI IAIKFLLSFL QKYPLNLFIY 250 YRWFLAVVIF LLYFFRN

References

[1]

"The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87." Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51303 / DSM 11347 / YP87.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001147 Genomic DNA. Translation: ACI22011.1.
RefSeq	YP_002249769.1. NC_011296.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	289376.THEYE_A1979.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACI22011; ACI22011; THEYE_A1979.
GeneID	6942160.
KEGG	tye:THEYE_A1979.
PATRIC	23910985. VBITheYel104483_1934.
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	DWQREEW.
Enzyme and pathway databases
BioCyc	TYEL289376:GH9L-1968-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_THEYD

Accession

Primary (citable) accession number: B5YID8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 25, 2008
Last modified:	May 29, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program