B5YHH6 (GSA_THEYD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	THEYE_A0147

Organism

Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) [Reference proteome] [HAMAP]

Taxonomic identifier

289376 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Nitrospirae › Nitrospira › Nitrospirales › Nitrospiraceae › Thermodesulfovibrio › Thermodesulfovibrio yellowstonii

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_1000121928
Amino acid modifications
	Modified residue	267	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5YHH6 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 62C935386B030A3E	FASTA	427	46,501
	10 20 30 40 50 60 MKTTKSKKLY KQALKLMPGG VNSPVRAFKA VGGNPLFIAK AKGSKIYDVD GNEYIDYVLS 70 80 90 100 110 120 WGPLILGHAY PSVVKALKKA IEKGTSYGAP TELEIKLATL VKKAFPSIEK LRFVNSGTEA 130 140 150 160 170 180 TMSAIRVARG FTKRNKVIKF EGCYHGHVDG LLVSAGSGGA TFSIPDSLGV PQSYTSETIV 190 200 210 220 230 240 LPFNDINTFK NTLKEHWKDI ACVIVEPVVG NMGCILPKDE FLKVLRNETQ KYGIVLIFDE 250 260 270 280 290 300 VMTGFRVSFG GAQQYYGVKP DLTCLGKVIG GGLPVGAYGG KKEIMALVAP DGGVYQAGTL 310 320 330 340 350 360 SGNPIAMTAG IETLKVLSKA SVYKRLEKTM QYLEEGLKDS AKQAGINVKF YRAGTMFCTY 370 380 390 400 410 420 FTENEVIDAK TAKTSDTEKF KQFFLGMLQK GVYIAPSQFE AGFISLAHSE KDIEKTVQAA YKIFKKL

References

[1]

"The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87." Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51303 / DSM 11347 / YP87.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001147 Genomic DNA. Translation: ACI20727.1.
RefSeq	YP_002247998.1. NC_011296.1.
3D structure databases
ProteinModelPortal	B5YHH6.
ModBase	Search...
Protein-protein interaction databases
STRING	289376.THEYE_A0147.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACI20727; ACI20727; THEYE_A0147.
GeneID	6942584.
KEGG	tye:THEYE_A0147.
PATRIC	23907315. VBITheYel104483_0144.
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	VEMIRMT.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_THEYD

Accession

Primary (citable) accession number: B5YHH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program