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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTYEL289376:G1GCQ-1318-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:THEYE_A1326
OrganismiThermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Taxonomic identifieri289376 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeThermodesulfovibrio
Proteomesi
  • UP000000718 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei235 – 255HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906831 – 361Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST361

Interactioni

Protein-protein interaction databases

STRINGi289376.THEYE_A1326

Structurei

3D structure databases

SMRiB5YFT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
InParanoidiB5YFT8
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B5YFT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYEILYSLS DYISGLNVFK YITFRTMLAI LTSFFFTFII APPCIRWLKK
60 70 80 90 100
LSLTQHIRDD GPKTHLKKEG TPTMGGIIIT ASVLVAVLMW GNLKNHYMWI
110 120 130 140 150
MIISFLGFGL IGFIDDYLKI TRKNYKGLPG RYKLFAQLLL ASSVTLFLYF
160 170 180 190 200
NPKDPYTTVL SIPFFKQWLI DLGIFYLPFA IFVIVGSSNA VNLTDGMDGL
210 220 230 240 250
AAGLVGIASI VNAVLLYISG HAVFAKYLYV LYIPGTGELA VFCGAMLGAC
260 270 280 290 300
LGFLWYNSYP AEVFMGDVGS LSLGGALGSL AVITKHEIVL ALVGGIFVVE
310 320 330 340 350
ALSVILQVGY FKLTNGKRIF RMAPLHHHFE LKKWPEPKVI VRFWIIGIIL
360
ALLSLLTLKL R
Length:361
Mass (Da):40,236
Last modified:November 25, 2008 - v1
Checksum:i00D95F81D072E14B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001147 Genomic DNA Translation: ACI21155.1
RefSeqiWP_012545877.1, NC_011296.1
YP_002249136.1, NC_011296.1

Genome annotation databases

EnsemblBacteriaiACI21155; ACI21155; THEYE_A1326
GeneIDi6943151
KEGGitye:THEYE_A1326
PATRICifig|289376.4.peg.1293

Similar proteinsi

Entry informationi

Entry nameiMRAY_THEYD
AccessioniPrimary (citable) accession number: B5YFT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: February 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health