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B5YFH2

- PYRF_DICT6

UniProt

B5YFH2 - PYRF_DICT6

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, DICTH_1461
Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121Substrate By similarity
Binding sitei34 – 341Substrate By similarity
Active sitei63 – 631Proton donor By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei196 – 1961Substrate By similarity
Binding sitei216 – 2161Substrate; via amide nitrogen By similarity
Binding sitei217 – 2171Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciDTHE309799:GHF9-1448-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:DICTH_1461
OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Taxonomic identifieri309799 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000001733: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000164566Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi309799.DICTH_1461.

Structurei

3D structure databases

ProteinModelPortaliB5YFH2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 7010Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiVIASPWE.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5YFH2-1 [UniParc]FASTAAdd to Basket

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MRKYDPIIVA LDFPEERKAL EVAEKIIPYV KNFKVGLELF SVAGPHIVKA    50
LKEMGTNVFI DLKLFDIPNT VVRTLDRLLT LDPFMVTLHI LGGEEMLRES 100
VKLVSQYKES NKTEYPYLLG VTVLTSFNEE TLRRSWGISR SLPEQVLFLA 150
QLAQETGLDG VIASPWEIEL LRNNLRRPML IVTPGIRLTK DKTDDQQRIM 200
TPREALERGS DYLVIGRPIT QSSDPYEVIR NIRSQIEDIV ESRL 244
Length:244
Mass (Da):27,966
Last modified:November 25, 2008 - v1
Checksum:i15FBBFBE92E6E126
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001146 Genomic DNA. Translation: ACI18378.1.
RefSeqiYP_002251280.1. NC_011297.1.

Genome annotation databases

EnsemblBacteriaiACI18378; ACI18378; DICTH_1461.
GeneIDi6946149.
KEGGidth:DICTH_1461.
PATRICi21807546. VBIDicThe33784_1404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001146 Genomic DNA. Translation: ACI18378.1 .
RefSeqi YP_002251280.1. NC_011297.1.

3D structure databases

ProteinModelPortali B5YFH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309799.DICTH_1461.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI18378 ; ACI18378 ; DICTH_1461 .
GeneIDi 6946149.
KEGGi dth:DICTH_1461.
PATRICi 21807546. VBIDicThe33784_1404.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi VIASPWE.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci DTHE309799:GHF9-1448-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35947 / DSM 3960 / H-6-12.

Entry informationi

Entry nameiPYRF_DICT6
AccessioniPrimary (citable) accession number: B5YFH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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