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B5YFB8 (GCSPA_DICT6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:DICTH_1407
OrganismDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) [Complete proteome] [HAMAP]
Taxonomic identifier309799 [NCBI]
Taxonomic lineageBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147984

Sequences

Sequence LengthMass (Da)Tools
B5YFB8 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 94E3F80D42FA1089

FASTA45351,031
        10         20         30         40         50         60 
MTYFPHTPQE IKEMLNTIGL ESIEDLFSEI PEEIRQKAKE NFKIPASPSE IDLLEEIKNI 

        70         80         90        100        110        120 
ARKNIGKDYI SFLGGGAYKH YIPPFVKLVS LFPTFYTAYT PYQPEISQGV LQSIFEYQSL 

       130        140        150        160        170        180 
ICDLTGMEVA NASLYEAGSG IAEAALMSVR ITGKKEVIAS SGLNPEYISV LKTYLQAQNI 

       190        200        210        220        230        240 
ELKIIPLDEK GETDVDFLEK NISPKTSGVI IQNPNFFGVI ETKLKDIEEL IHKNNALFIL 

       250        260        270        280        290        300 
SIYPISLGIL KPPSEYNVDI VVGEGQSLGI PLGFGGPYLG ILATKKEFIR QIPGRIVGET 

       310        320        330        340        350        360 
IDLEGERGFV NTLQTREQHI RRAKATSNIC TNEALSAISA AVYMAILGKK GIKKIAEVCF 

       370        380        390        400        410        420 
SRAHYLRERM QKEVNLEITY PNSHFFNEFV IKIPENSENF LKKLEEKKIL GGIPLSRFYK 

       430        440        450 
DRDKEILVAV TERNSLEELE YYIKSLKEVL KKN 

« Hide

References

[1]"The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35947 / DSM 3960 / H-6-12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001146 Genomic DNA. Translation: ACI19857.1.
RefSeqYP_002251226.1. NC_011297.1.

3D structure databases

ProteinModelPortalB5YFB8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309799.DICTH_1407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI19857; ACI19857; DICTH_1407.
GeneID6945683.
KEGGdth:DICTH_1407.
PATRIC21807438. VBIDicThe33784_1350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBCLSK2409990.

Enzyme and pathway databases

BioCycDTHE309799:GHF9-1394-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_DICT6
AccessionPrimary (citable) accession number: B5YFB8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families