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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciDTHE309799:G1GCP-1246-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:DICTH_1286
OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Taxonomic identifieri309799 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000932511 – 220Protein-L-isoaspartate O-methyltransferaseAdd BLAST220

Proteomic databases

PRIDEiB5YF00

Interactioni

Protein-protein interaction databases

STRINGi309799.DICTH_1286

Structurei

3D structure databases

ProteinModelPortaliB5YF00
SMRiB5YF00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26 Bacteria
COG2518 LUCA
HOGENOMiHOG000257189
KOiK00573
OMAiPYTVAFQ
OrthoDBiPOG091H06AY

Family and domain databases

HAMAPiMF_00090 PIMT, 1 hit
InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit
PROSITEiView protein in PROSITE
PS01279 PCMT, 1 hit

Sequencei

Sequence statusi: Complete.

B5YF00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKKFDTPE YEHKRRKLVE ILKDEGIKSQ KVLNAILKIP RHMFVPQEYL
60 70 80 90 100
SLSYENEALP IGYGQTISQP YIVALMTEAL NLQGNEKVLE IGTGSGYQTA
110 120 130 140 150
ILAELALEIY TVERIKELLE EAKKRLRVLG YNNVYFKLGD GTLGWEEFAP
160 170 180 190 200
YDRIIVTAAS YDIPEPLKEQ LKDGGIMVIP IGGRDFQYLY RITKKGDNFY
210 220
RENLGGVRFV PLKGEYGWKD
Length:220
Mass (Da):25,279
Last modified:November 25, 2008 - v1
Checksum:i708357FAC95853D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001146 Genomic DNA Translation: ACI19465.1
RefSeqiWP_012548097.1, NC_011297.1

Genome annotation databases

EnsemblBacteriaiACI19465; ACI19465; DICTH_1286
KEGGidth:DICTH_1286

Entry informationi

Entry nameiPIMT_DICT6
AccessioniPrimary (citable) accession number: B5YF00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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