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B5YDQ0 (B5YDQ0_DICT6) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:DICTH_0792
OrganismDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) [Complete proteome] [HAMAP]
Taxonomic identifier309799 [NCBI]
Taxonomic lineageBacteria › Dictyoglomi › Dictyoglomales › Dictyoglomaceae › Dictyoglomus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region253 – 2575ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2521 By similarity HAMAP MF_01815
Active site2821 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B5YDQ0 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 4474920D88D1FC5A

FASTA32835,228
        10         20         30         40         50         60 
MGVGIVGIGT AVPPRILTNF DLEKMVDTSD EWITTRTGIK ERRIADKDTN PSDLGAEAAL 

        70         80         90        100        110        120 
KAIEMAKISP EDIDLIIVTS ASLEMVFPSM AAIIQNKIGA KNAGGFDLLS ACTGFVSSLI 

       130        140        150        160        170        180 
TGAQFIRTGD VKTVLVIGTE VLSRFIDWED RNTCVLFGDG AGAVVLREVG DNYGLLSWSL 

       190        200        210        220        230        240 
HLDGSGADLL AIPGGCARNP CSEEVLKNKL HYIKMNGREV FKFSVKVIGE VTEEALSKAS 

       250        260        270        280        290        300 
LTSKDLDWLV PHQANVRIIE AGAERLGIPL DKVAINLQKY GNTSTASIPL ALEELIRDKK 

       310        320 
LKDGDIVALV GFGAGLSWGS AIMRWKEI

« Hide

References

[1]"The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001146 Genomic DNA. Translation: ACI19723.1.
RefSeqYP_002250658.1. NC_011297.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB5YDQ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6945334.
GenomeReviewsGene locus DICTH_0792 in contig CP001146_GR.
KEGGdth:DICTH_0792.
PATRIC21806222. VBIDicThe33784_0779.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAMAKISPE.
ProtClustDBCLSK2409913.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB5YDQ0_DICT6
AccessionPrimary (citable) accession number: B5YDQ0
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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