B5YDD0 (B5YDD0_DICT6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL ACI18727.1
EC=2.4.1.182 EMBL ACI18727.1

Gene names

Name:	lpxB EMBL ACI18727.1
Ordered Locus Names:	DICTH_0665

Organism

Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) [Complete proteome] [HAMAP]

Taxonomic identifier

309799 [NCBI]

Taxonomic lineage

Bacteria › Dictyoglomi › Dictyoglomales › Dictyoglomaceae › Dictyoglomus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ACI18727.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5YDD0 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 19F5ACB02DDEED84	FASTA	363	41,887
	10 20 30 40 50 60 MKIFLSALEV SADIHGAKLI NALKNKAKNI YFYGLGGERM KEEGMEVLYD VTQYSTVGFV 70 80 90 100 110 120 EPIPYIPKLL LVQERVKRII KETKPDLIIF IDAQGFNLPL AKYAKKLGLK TIYYFAPQYW 130 140 150 160 170 180 LWGDKKKVKE VLDSLSYVIA TFPQEYELYR SFGDNVVYYG HPLVDYLLPY KDLEREKNII 190 200 210 220 230 240 GLFPGSRIQE IKNLTPIFLE IADRLKVNGY RFVMPIASEK FSNLVFEYVR GKDHIELVSG 250 260 270 280 290 300 KESQKYLKIS SLSLVASGTV TLEAAILKTP AMVFYKISPV TYHIAKRLVH YTFIALPNII 310 320 330 340 350 360 LNQMIYPEFI QKIDIEEVMT NIGRILKDDI YRKNLEDKLK ELETKLGQPG VLDRISNFIL EII

References

[1]	"The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12." Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001146 Genomic DNA. Translation: ACI18727.1.
RefSeq	YP_002250538.1. NC_011297.1.
3D structure databases
ProteinModelPortal	B5YDD0.
ModBase	Search...
Protein-protein interaction databases
STRING	B5YDD0.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6946461.
GenomeReviews	Gene locus DICTH_0665 in contig CP001146_GR.
KEGG	dth:DICTH_0665.
PATRIC	21805974. VBIDicThe33784_0661.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
ProtClustDB	CLSK2409339.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B5YDD0_DICT6

Accession

Primary (citable) accession number: B5YDD0

Entry history

Integrated into UniProtKB/TrEMBL:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)