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B5YDB0

- KITH_DICT6

UniProt

B5YDB0 - KITH_DICT6

Protein

Thymidine kinase

Gene

tdk

Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Proton acceptorUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi149 – 1491ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238ATPUniRule annotation
    Nucleotide bindingi89 – 924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciDTHE309799:GHF9-639-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:DICTH_0645
    OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
    Taxonomic identifieri309799 [NCBI]
    Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
    ProteomesiUP000001733: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Thymidine kinasePRO_1000095432Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi309799.DICTH_0645.

    Structurei

    3D structure databases

    ProteinModelPortaliB5YDB0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiDHISEST.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5YDB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEILNGPSGW IEVICGGMYS GKSEELIRRV RRAQIAKQKV QVFKHSLDIR    50
    YDKDYVASHT GLKIEAIPVS SSADIERLVE DDTQVVAIEE GQFFDMGIVK 100
    VCQRLADKGK RVIVAGLDQD FRGEPFGPMP YLMAVAEYVD KLHAICMKCG 150
    NVASRTQRII DGKPAYYDDP IILVGAFETY EARCRNCHIV LRRDENEK 198
    Length:198
    Mass (Da):22,357
    Last modified:November 25, 2008 - v1
    Checksum:i09BA3D44D5980948
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001146 Genomic DNA. Translation: ACI19253.1.
    RefSeqiWP_012547885.1. NC_011297.1.
    YP_002250518.1. NC_011297.1.

    Genome annotation databases

    EnsemblBacteriaiACI19253; ACI19253; DICTH_0645.
    GeneIDi6945023.
    KEGGidth:DICTH_0645.
    PATRICi21805934. VBIDicThe33784_0641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001146 Genomic DNA. Translation: ACI19253.1 .
    RefSeqi WP_012547885.1. NC_011297.1.
    YP_002250518.1. NC_011297.1.

    3D structure databases

    ProteinModelPortali B5YDB0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309799.DICTH_0645.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI19253 ; ACI19253 ; DICTH_0645 .
    GeneIDi 6945023.
    KEGGi dth:DICTH_0645.
    PATRICi 21805934. VBIDicThe33784_0641.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi DHISEST.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci DTHE309799:GHF9-639-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
      Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35947 / DSM 3960 / H-6-12.

    Entry informationi

    Entry nameiKITH_DICT6
    AccessioniPrimary (citable) accession number: B5YDB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3