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B5YD88 (DNLI_DICT6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:DICTH_0616
OrganismDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) [Complete proteome] [HAMAP]
Taxonomic identifier309799 [NCBI]
Taxonomic lineageBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365219

Sites

Active site2451N6-AMP-lysine intermediate By similarity
Binding site2431ATP By similarity
Binding site2501ATP By similarity
Binding site2651ATP By similarity
Binding site2951ATP By similarity
Binding site3351ATP By similarity
Binding site4101ATP By similarity
Binding site4161ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B5YD88 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 5AB0045336097A03

FASTA58266,791
        10         20         30         40         50         60 
MLFGELAQYF ERIEKTTKRN EMMEILADLF RKVDKEEIDK IIYLLNGRVA PDYEKIEFGM 

        70         80         90        100        110        120 
SDKLVLRAMA LALKIPLLEL ERSYKEVGDL GELVVKYSKN EGKDLTVVET FNTLYDIANL 

       130        140        150        160        170        180 
SGEGSVDAKV NRLAFLINSL TPQGGKYLVR IVLGKLRLGV GEPTIMDALS FAKVKDKGLR 

       190        200        210        220        230        240 
PFIERAFNIT SDLGYVAKVF WEGGVEALKR IKVQVGRPIR MALAERVSRA EEIIKRLGKC 

       250        260        270        280        290        300 
AVEPKFDGFR CQIHKKENSV RIFSRNLEDN TYMFPDLVEA VLKQFPDRDV IIEGEAISYN 

       310        320        330        340        350        360 
PETGEFYPFQ VTVQRKRKYN ISEMVELYPL QLFAFDILYL DGEDTTSLPY IRRRQKLEEA 

       370        380        390        400        410        420 
LVEGEKISIT KNIITNDPKE IQSFFEECIT EGLEGIVAKR LDAPYQAGMR NFNWIKLKRS 

       430        440        450        460        470        480 
YQGHLADTVD CVILGYFKGR GHRAKFGIGA LLVGVYDDER DLFKTIAKIG TGPTEEEWVK 

       490        500        510        520        530        540 
FREILDEIKV EKRPNNVESF IEPDVWVEPK YVVVVQADEI TRSPVHTCGR ELDGLGYALR 

       550        560        570        580 
FPRVQGFVRE DKGPYDATTV KEILEMFRNQ KKEKVEEDSD LL 

« Hide

References

[1]"The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35947 / DSM 3960 / H-6-12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001146 Genomic DNA. Translation: ACI19645.1.
RefSeqYP_002250496.1. NC_011297.1.

3D structure databases

ProteinModelPortalB5YD88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309799.DICTH_0616.

Proteomic databases

PRIDEB5YD88.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI19645; ACI19645; DICTH_0616.
GeneID6946484.
KEGGdth:DICTH_0616.
PATRIC21805882. VBIDicThe33784_0619.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAGEFYPFQ.
OrthoDBEOG6Q8HXT.

Enzyme and pathway databases

BioCycDTHE309799:GHF9-613-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_DICT6
AccessionPrimary (citable) accession number: B5YD88
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families