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B5YD88

- DNLI_DICT6

UniProt

B5YD88 - DNLI_DICT6

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Protein

Probable DNA ligase

Gene
lig, DICTH_0616
Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei243 – 2431ATP By similarity
Active sitei245 – 2451N6-AMP-lysine intermediate By similarity
Binding sitei250 – 2501ATP By similarity
Binding sitei265 – 2651ATP By similarity
Binding sitei295 – 2951ATP By similarity
Binding sitei335 – 3351ATP By similarity
Binding sitei410 – 4101ATP By similarity
Binding sitei416 – 4161ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDTHE309799:GHF9-613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:DICTH_0616
OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Taxonomic identifieri309799 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000001733: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Probable DNA ligaseUniRule annotationPRO_0000365219Add
BLAST

Proteomic databases

PRIDEiB5YD88.

Interactioni

Protein-protein interaction databases

STRINGi309799.DICTH_0616.

Structurei

3D structure databases

ProteinModelPortaliB5YD88.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGEFYPFQ.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5YD88-1 [UniParc]FASTAAdd to Basket

« Hide

MLFGELAQYF ERIEKTTKRN EMMEILADLF RKVDKEEIDK IIYLLNGRVA    50
PDYEKIEFGM SDKLVLRAMA LALKIPLLEL ERSYKEVGDL GELVVKYSKN 100
EGKDLTVVET FNTLYDIANL SGEGSVDAKV NRLAFLINSL TPQGGKYLVR 150
IVLGKLRLGV GEPTIMDALS FAKVKDKGLR PFIERAFNIT SDLGYVAKVF 200
WEGGVEALKR IKVQVGRPIR MALAERVSRA EEIIKRLGKC AVEPKFDGFR 250
CQIHKKENSV RIFSRNLEDN TYMFPDLVEA VLKQFPDRDV IIEGEAISYN 300
PETGEFYPFQ VTVQRKRKYN ISEMVELYPL QLFAFDILYL DGEDTTSLPY 350
IRRRQKLEEA LVEGEKISIT KNIITNDPKE IQSFFEECIT EGLEGIVAKR 400
LDAPYQAGMR NFNWIKLKRS YQGHLADTVD CVILGYFKGR GHRAKFGIGA 450
LLVGVYDDER DLFKTIAKIG TGPTEEEWVK FREILDEIKV EKRPNNVESF 500
IEPDVWVEPK YVVVVQADEI TRSPVHTCGR ELDGLGYALR FPRVQGFVRE 550
DKGPYDATTV KEILEMFRNQ KKEKVEEDSD LL 582
Length:582
Mass (Da):66,791
Last modified:November 25, 2008 - v1
Checksum:i5AB0045336097A03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001146 Genomic DNA. Translation: ACI19645.1.
RefSeqiYP_002250496.1. NC_011297.1.

Genome annotation databases

EnsemblBacteriaiACI19645; ACI19645; DICTH_0616.
GeneIDi6946484.
KEGGidth:DICTH_0616.
PATRICi21805882. VBIDicThe33784_0619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001146 Genomic DNA. Translation: ACI19645.1 .
RefSeqi YP_002250496.1. NC_011297.1.

3D structure databases

ProteinModelPortali B5YD88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309799.DICTH_0616.

Proteomic databases

PRIDEi B5YD88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI19645 ; ACI19645 ; DICTH_0616 .
GeneIDi 6946484.
KEGGi dth:DICTH_0616.
PATRICi 21805882. VBIDicThe33784_0619.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi GEFYPFQ.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci DTHE309799:GHF9-613-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35947 / DSM 3960 / H-6-12.

Entry informationi

Entry nameiDNLI_DICT6
AccessioniPrimary (citable) accession number: B5YD88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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