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B5YCT4

- GCH4_DICT6

UniProt

B5YCT4 - GCH4_DICT6

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1431May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciDTHE309799:GHF9-458-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:DICTH_0460
    OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
    Taxonomic identifieri309799 [NCBI]
    Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
    ProteomesiUP000001733: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257GTP cyclohydrolase FolE2PRO_1000215388Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309799.DICTH_0460.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiLIWFEDL.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5YCT4-1 [UniParc]FASTAAdd to Basket

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    MRDVQNEKDY RGIYLRKVGI KNIHWPIKIV TKSGDYQSTV ASIDISVDLR    50
    EDLRGTHMSR FVEVLNGIDS LHPENLGKIL QEVREKLRAD SSHIKISFPY 100
    FIFKKAPVSQ ISSPNMVECV IDAELSKKLD MIIGVKVPIH TLCPCSKEIS 150
    EYGAHNQRGV AEIYVRSKKL IWFEDLVEIS EKSASAPIYS LLKRPDEKYI 200
    TEMAYNNPKF VEDVVRDIVS ELEKEPKISW YRVEVTSFES IHNHNAFACV 250
    EKGWVKK 257
    Length:257
    Mass (Da):29,584
    Last modified:November 25, 2008 - v1
    Checksum:i57766687A35C7334
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001146 Genomic DNA. Translation: ACI18288.1.
    RefSeqiWP_012546920.1. NC_011297.1.
    YP_002250342.1. NC_011297.1.

    Genome annotation databases

    EnsemblBacteriaiACI18288; ACI18288; DICTH_0460.
    GeneIDi6945972.
    KEGGidth:DICTH_0460.
    PATRICi21805570. VBIDicThe33784_0463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001146 Genomic DNA. Translation: ACI18288.1 .
    RefSeqi WP_012546920.1. NC_011297.1.
    YP_002250342.1. NC_011297.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309799.DICTH_0460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI18288 ; ACI18288 ; DICTH_0460 .
    GeneIDi 6945972.
    KEGGi dth:DICTH_0460.
    PATRICi 21805570. VBIDicThe33784_0463.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi LIWFEDL.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci DTHE309799:GHF9-458-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
      Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35947 / DSM 3960 / H-6-12.

    Entry informationi

    Entry nameiGCH4_DICT6
    AccessioniPrimary (citable) accession number: B5YCT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3