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B5YC89

- B5YC89_DICT6

UniProt

B5YC89 - B5YC89_DICT6

Protein

Isocitrate dehydrogenase [NADP]

Gene

DICTH_1941

Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771Substrate
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091Substrate
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei209 – 2091Critical for catalysisUniRule annotation
    Metal bindingi248 – 2481Magnesium or manganeseUniRule annotation
    Binding sitei256 – 2561NADPUniRule annotation
    Metal bindingi271 – 2711Magnesium or manganeseUniRule annotation
    Binding sitei323 – 3231NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi305 – 3106NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciDTHE309799:GHF9-1924-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:DICTH_1941Imported
    OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)Imported
    Taxonomic identifieri309799 [NCBI]
    Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
    ProteomesiUP000001733: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi309799.DICTH_1941.

    Structurei

    3D structure databases

    ProteinModelPortaliB5YC89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiEANWRSK.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5YC89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIKVKNPI VELDGDEMAR VMWKWIKEEL IFPYLDIPIK YFDLGIQNRD    50
    ATSDMVTLEA AKAIKEYKVG VKCATITPDQ ERVKEYNLKK AWKSPNATIR 100
    AYLDGTVFRK PIIVKNIPPY VKTWKRPIII GRHAYGDIYN AFEYRVEEPI 150
    EVEIVLRSGS EVKNFKVHSF DGKGVFMLLH NTEKSIRSFA RSCINYALSE 200
    KVDLWFSAKD TISKIYHGYF KEIFQEEVER RKDDFEKAGI NYRYFLIDDA 250
    VAQILKSEGG MLWACMNYEG DVMSDMIAAG FGSLGLMTSV LVSPEGEYEF 300
    EAAHGTVRRH YYEYLKGNKT STNPTASIFA WTGGIRKRGE LDDTPEVVNF 350
    ADKLEEATIK TIESGIMTKD LQPLADPPVD RYYYTEDFIR AIKERLESLL 400
    KN 402
    Length:402
    Mass (Da):46,321
    Last modified:November 25, 2008 - v1
    Checksum:i840ED98E58FD518E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001146 Genomic DNA. Translation: ACI19194.1.
    RefSeqiWP_012547826.1. NC_011297.1.
    YP_002251750.1. NC_011297.1.

    Genome annotation databases

    EnsemblBacteriaiACI19194; ACI19194; DICTH_1941.
    GeneIDi6945004.
    KEGGidth:DICTH_1941.
    PATRICi21808506. VBIDicThe33784_1880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001146 Genomic DNA. Translation: ACI19194.1 .
    RefSeqi WP_012547826.1. NC_011297.1.
    YP_002251750.1. NC_011297.1.

    3D structure databases

    ProteinModelPortali B5YC89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309799.DICTH_1941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI19194 ; ACI19194 ; DICTH_1941 .
    GeneIDi 6945004.
    KEGGi dth:DICTH_1941.
    PATRICi 21808506. VBIDicThe33784_1880.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi EANWRSK.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci DTHE309799:GHF9-1924-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
      Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35947 / DSM 3960 / H-6-12Imported.

    Entry informationi

    Entry nameiB5YC89_DICT6
    AccessioniPrimary (citable) accession number: B5YC89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 25, 2008
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3