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B5YC89

- B5YC89_DICT6

UniProt

B5YC89 - B5YC89_DICT6

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Protein

Isocitrate dehydrogenase [NADP]

Gene

DICTH_1941

Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091Substrate
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei209 – 2091Critical for catalysisUniRule annotation
Metal bindingi248 – 2481Magnesium or manganeseUniRule annotation
Binding sitei256 – 2561NADPUniRule annotation
Metal bindingi271 – 2711Magnesium or manganeseUniRule annotation
Binding sitei323 – 3231NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi305 – 3106NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDTHE309799:GHF9-1924-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:DICTH_1941Imported
OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)Imported
Taxonomic identifieri309799 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000001733: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi309799.DICTH_1941.

Structurei

3D structure databases

ProteinModelPortaliB5YC89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiEANWRSK.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

B5YC89-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIKVKNPI VELDGDEMAR VMWKWIKEEL IFPYLDIPIK YFDLGIQNRD
60 70 80 90 100
ATSDMVTLEA AKAIKEYKVG VKCATITPDQ ERVKEYNLKK AWKSPNATIR
110 120 130 140 150
AYLDGTVFRK PIIVKNIPPY VKTWKRPIII GRHAYGDIYN AFEYRVEEPI
160 170 180 190 200
EVEIVLRSGS EVKNFKVHSF DGKGVFMLLH NTEKSIRSFA RSCINYALSE
210 220 230 240 250
KVDLWFSAKD TISKIYHGYF KEIFQEEVER RKDDFEKAGI NYRYFLIDDA
260 270 280 290 300
VAQILKSEGG MLWACMNYEG DVMSDMIAAG FGSLGLMTSV LVSPEGEYEF
310 320 330 340 350
EAAHGTVRRH YYEYLKGNKT STNPTASIFA WTGGIRKRGE LDDTPEVVNF
360 370 380 390 400
ADKLEEATIK TIESGIMTKD LQPLADPPVD RYYYTEDFIR AIKERLESLL

KN
Length:402
Mass (Da):46,321
Last modified:November 25, 2008 - v1
Checksum:i840ED98E58FD518E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001146 Genomic DNA. Translation: ACI19194.1.
RefSeqiYP_002251750.1. NC_011297.1.

Genome annotation databases

EnsemblBacteriaiACI19194; ACI19194; DICTH_1941.
GeneIDi6945004.
KEGGidth:DICTH_1941.
PATRICi21808506. VBIDicThe33784_1880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001146 Genomic DNA. Translation: ACI19194.1 .
RefSeqi YP_002251750.1. NC_011297.1.

3D structure databases

ProteinModelPortali B5YC89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309799.DICTH_1941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI19194 ; ACI19194 ; DICTH_1941 .
GeneIDi 6945004.
KEGGi dth:DICTH_1941.
PATRICi 21808506. VBIDicThe33784_1880.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi EANWRSK.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci DTHE309799:GHF9-1924-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35947 / DSM 3960 / H-6-12Imported.

Entry informationi

Entry nameiB5YC89_DICT6
AccessioniPrimary (citable) accession number: B5YC89
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3