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B5YC89 (B5YC89_DICT6) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:DICTH_1941 EMBL ACI19194.1
OrganismDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) [Complete proteome] [HAMAP] EMBL ACI19194.1
Taxonomic identifier309799 [NCBI]
Taxonomic lineageBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding305 – 3106NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2481Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2711Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2561NADP By similarity PIRSR PIRSR000108-4
Binding site3231NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2091Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
B5YC89 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 840ED98E58FD518E

FASTA40246,321
        10         20         30         40         50         60 
MKKIKVKNPI VELDGDEMAR VMWKWIKEEL IFPYLDIPIK YFDLGIQNRD ATSDMVTLEA 

        70         80         90        100        110        120 
AKAIKEYKVG VKCATITPDQ ERVKEYNLKK AWKSPNATIR AYLDGTVFRK PIIVKNIPPY 

       130        140        150        160        170        180 
VKTWKRPIII GRHAYGDIYN AFEYRVEEPI EVEIVLRSGS EVKNFKVHSF DGKGVFMLLH 

       190        200        210        220        230        240 
NTEKSIRSFA RSCINYALSE KVDLWFSAKD TISKIYHGYF KEIFQEEVER RKDDFEKAGI 

       250        260        270        280        290        300 
NYRYFLIDDA VAQILKSEGG MLWACMNYEG DVMSDMIAAG FGSLGLMTSV LVSPEGEYEF 

       310        320        330        340        350        360 
EAAHGTVRRH YYEYLKGNKT STNPTASIFA WTGGIRKRGE LDDTPEVVNF ADKLEEATIK 

       370        380        390        400 
TIESGIMTKD LQPLADPPVD RYYYTEDFIR AIKERLESLL KN 

« Hide

References

[1]"The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35947 / DSM 3960 / H-6-12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001146 Genomic DNA. Translation: ACI19194.1.
RefSeqYP_002251750.1. NC_011297.1.

3D structure databases

ProteinModelPortalB5YC89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309799.DICTH_1941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI19194; ACI19194; DICTH_1941.
GeneID6945004.
KEGGdth:DICTH_1941.
PATRIC21808506. VBIDicThe33784_1880.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycDTHE309799:GHF9-1924-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB5YC89_DICT6
AccessionPrimary (citable) accession number: B5YC89
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)