Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119 – 120Important for bifunctional activityUniRule annotation2
Binding sitei122dCTPUniRule annotation1
Active sitei132Proton donor/acceptorUniRule annotation1
Binding sitei151dCTPUniRule annotation1
Binding sitei165dCTPUniRule annotation1
Binding sitei172dCTPUniRule annotation1
Binding sitei176dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 109dCTP bindingUniRule annotation6
Nucleotide bindingi130 – 132dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciDTHE309799:G1GCP-1707-MONOMER
UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:DICTH_1754
OrganismiDictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Taxonomic identifieri309799 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000001733 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000964211 – 194dCTP deaminase, dUMP-formingAdd BLAST194

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi309799.DICTH_1754

Structurei

3D structure databases

ProteinModelPortaliB5YB40
SMRiB5YB40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiGWIDAGF
OrthoDBiPOG091H021I

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

B5YB40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDRDIKK YLEEGKLVIH PIDDPQKQIQ PSSVDLRLGN SFLHFKVEGR
60 70 80 90 100
AYIDPTQDSP QELMEIIEIE EGKPFFLRPG EFVLGTTIET VKLPDDLVAR
110 120 130 140 150
VDGRSSLGRL GIIVHATAGY VDPGFCGQIT LELSNINRVP VALYPGMRIC
160 170 180 190
QISFYKLSSP AETPYYKKAG SKYHNQKGPT ASRLNIDFCK KEEK
Length:194
Mass (Da):21,797
Last modified:November 25, 2008 - v1
Checksum:i922AE192D5DB59A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001146 Genomic DNA Translation: ACI19502.1
RefSeqiWP_012548134.1, NC_011297.1

Genome annotation databases

EnsemblBacteriaiACI19502; ACI19502; DICTH_1754
KEGGidth:DICTH_1754

Similar proteinsi

Entry informationi

Entry nameiDCDB_DICT6
AccessioniPrimary (citable) accession number: B5YB40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health