B5YA74 (B5YA74_DICT6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543 EMBL ACI20020.1
Ordered Locus Names:	DICTH_1527

Organism

Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) [Complete proteome] [HAMAP]

Taxonomic identifier

309799 [NCBI]

Taxonomic lineage

Bacteria › Dictyoglomi › Dictyoglomales › Dictyoglomaceae › Dictyoglomus

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ACI20020.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	53 – 60	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B5YA74 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: A84C8D8EA4CF8E5E	FASTA	544	59,655
	10 20 30 40 50 60 MRRILEIISD LGIPEEFFIP YGWYIGKVKW DYYKEIQKNP SGKLILVSAM NPTPYGEGKT 70 80 90 100 110 120 TTTIGLGDAI RRLSYRSFVC IREPSMGPVF GIKGGAVGGG KAKVVPEDSI NLHFTGDIHA 130 140 150 160 170 180 VTSAHNLLSA LVDNHIYHGN ELNIDVRQIL WKRCLDMNDR QLRFVVSGLG GKANGVPRED 190 200 210 220 230 240 GFDITAASEV MAIISLSRSV SELKERLGNI IVGINKNNTP ILCKDIGAQG AMSVILKDAI 250 260 270 280 290 300 SPNLVQTLEG TPAFVHGGPF ANIAHGTNSL IATEMALRLS DYVVTEAGFG VDLGAEKFFD 310 320 330 340 350 360 IKCRLGNIRP SAVVIVASIR ALKFHGGVKK DFDNENMEAI KKGMSNLLHH VSVVRDVFKL 370 380 390 400 410 420 PVVVALNKFP KDEKKEIEYV ISELKERNIR VAISEVYEKG GLGGIQLAQE VIKAIEEDKN 430 440 450 460 470 480 EFSYLYDLSE SYKDKIEKIC KEVYGAKDVV FSENAKEELK KIEGWGFINL PVCMAKTQYS 490 500 510 520 530 540 LSDNPKLIGK PEDFVINVQG VKVSGGAGFL VVYTGNIMTM PGLPKVPSAF QMDLDDNGNI IGLS

References

[1]	"The complete genome sequence of Dictyoglomus thermophilum strain ATCC 35947 / DSM 3960 / H-6-12." Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001146 Genomic DNA. Translation: ACI20020.1.
RefSeq	YP_002251344.1. NC_011297.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B5YA74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6945438.
GenomeReviews	Gene locus DICTH_1527 in contig CP001146_GR.
KEGG	dth:DICTH_1527.
PATRIC	21807678. VBIDicThe33784_1469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	TDFTVTI.
ProtClustDB	CLSK2410079.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B5YA74_DICT6

Accession

Primary (citable) accession number: B5YA74

Entry history

Integrated into UniProtKB/TrEMBL:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)