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Protein

8-amino-7-oxononanoate synthase

Gene

COPRO5265_1289

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321SubstrateBy similarity
Binding sitei180 – 1801Pyridoxal phosphateBy similarity
Binding sitei353 – 3531SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-1277-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:COPRO5265_1289
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
Proteomesi
  • UP000001732 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3933938-amino-7-oxononanoate synthasePRO_0000380957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi309798.COPRO5265_1289.

Structurei

3D structure databases

ProteinModelPortaliB5Y9Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1082Pyridoxal phosphate bindingBy similarity
Regioni205 – 2084Pyridoxal phosphate bindingBy similarity
Regioni236 – 2394Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221022.
KOiK00639.
OMAiQYVIDAF.
OrthoDBiPOG091H024U.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5Y9Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVEEFEREL NERREQGLYV TIRKIGSPQG AWIIVDGKKV LNLSSNNYLG
60 70 80 90 100
FANHPRLKEA AKKGIDDYGA GPAAVRTIAG DQLPQEKLEE MLAEFKGAEA
110 120 130 140 150
AVLYQSGFCA NLGTIPALVG EGDAIFSDEL NHASIIDGCR LSRAKIIRYP
160 170 180 190 200
HLNVQTLEEL LKQERQNYKK AMIITDGVFS MDGDIAPMDK LADLADKYQC
210 220 230 240 250
ILYVDDAHGE GVLGDSGRGI VDYFGLQGRV DVEIGTLSKA FGVVGGFAAG
260 270 280 290 300
SKLLAELLKQ KARPLLFSSA PTAADVYASM EAVRILQESD ELVKKLWENA
310 320 330 340 350
NYFKEHMRKA GFDLGNSQTP ITPVMIGDEI TTQEFSKKLF ERNVFAQAIS
360 370 380 390
YPTVPKGKAR MRVMISATHS RDDLDFAVEQ FTAVGKELGV IQS
Length:393
Mass (Da):43,172
Last modified:July 28, 2009 - v2
Checksum:i3BD0DC81C61E15A4
GO

Sequence cautioni

The sequence ACI18052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA. Translation: ACI18052.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiACI18052; ACI18052; COPRO5265_1289.
KEGGicpo:COPRO5265_1289.
PATRICi21475378. VBICopPro72829_1195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA. Translation: ACI18052.1. Different initiation.

3D structure databases

ProteinModelPortaliB5Y9Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309798.COPRO5265_1289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI18052; ACI18052; COPRO5265_1289.
KEGGicpo:COPRO5265_1289.
PATRICi21475378. VBICopPro72829_1195.

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221022.
KOiK00639.
OMAiQYVIDAF.
OrthoDBiPOG091H024U.

Enzyme and pathway databases

UniPathwayiUPA00078.
BioCyciCPRO309798:GH7M-1277-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIOF_COPPD
AccessioniPrimary (citable) accession number: B5Y9Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 7, 2016
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.