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B5Y9D4

- GCSPA_COPPD

UniProt

B5Y9D4 - GCSPA_COPPD

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, COPRO5265_1070
Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-1061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:COPRO5265_1070
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
ProteomesiUP000001732: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000147981Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi309798.COPRO5265_1070.

Structurei

3D structure databases

ProteinModelPortaliB5Y9D4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B5Y9D4-1 [UniParc]FASTAAdd to Basket

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MRYVPHTKEE IKAMLEAVGL RNVDELFSDI PTEALLKRHL QVEGGWDEEQ    50
LRAYFRKAAS SIPDANSAVY FLGGGVYDHY VPSAVDKIIA LPEFYTAYTP 100
YQAEISQGTL QAMFEYQSLI CELTGMEVAN GSLYDGASAV AEAVLMAMRI 150
NGKRRVLVSE CVHPDIIEVL RTYQLGQDFE ILTLPQKEGV TDLSELEDLS 200
NVSCLVMQNP NYYGFLENMN QASELIHKAG GLFVAAVDPL SLGVLKSPHE 250
YGADVVVGEG QSLGNHMSYG GPHFGFFATK MDYIRYMPGR MAGQTVDVDG 300
RVGYVLTLQT REQHIRREKA TSNITSNHWL MALASAVYLS LMGGSLPELG 350
QTILNRSTYL AQKLASVGYP LWQRQYFFKE FPIKARDAEA VQEALADSGY 400
YVGPVIDEHT LLVAVTEKRT KEHMDKLIEL MEGLR 435
Length:435
Mass (Da):48,463
Last modified:November 25, 2008 - v1
Checksum:i663DD22E41615B15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI17103.1.
RefSeqiWP_012543755.1. NC_011295.1.
YP_002247381.1. NC_011295.1.

Genome annotation databases

EnsemblBacteriaiACI17103; ACI17103; COPRO5265_1070.
GeneIDi6943842.
KEGGicpo:COPRO5265_1070.
PATRICi21474958. VBICopPro72829_0989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI17103.1 .
RefSeqi WP_012543755.1. NC_011295.1.
YP_002247381.1. NC_011295.1.

3D structure databases

ProteinModelPortali B5Y9D4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 309798.COPRO5265_1070.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI17103 ; ACI17103 ; COPRO5265_1070 .
GeneIDi 6943842.
KEGGi cpo:COPRO5265_1070.
PATRICi 21474958. VBICopPro72829_0989.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CPRO309798:GH7M-1061-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35245 / DSM 5265 / BT.

Entry informationi

Entry nameiGCSPA_COPPD
AccessioniPrimary (citable) accession number: B5Y9D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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