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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-1061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:COPRO5265_1070
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
ProteomesiUP000001732 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147981Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi309798.COPRO5265_1070.

Structurei

3D structure databases

ProteinModelPortaliB5Y9D4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSMYDGST.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B5Y9D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYVPHTKEE IKAMLEAVGL RNVDELFSDI PTEALLKRHL QVEGGWDEEQ
60 70 80 90 100
LRAYFRKAAS SIPDANSAVY FLGGGVYDHY VPSAVDKIIA LPEFYTAYTP
110 120 130 140 150
YQAEISQGTL QAMFEYQSLI CELTGMEVAN GSLYDGASAV AEAVLMAMRI
160 170 180 190 200
NGKRRVLVSE CVHPDIIEVL RTYQLGQDFE ILTLPQKEGV TDLSELEDLS
210 220 230 240 250
NVSCLVMQNP NYYGFLENMN QASELIHKAG GLFVAAVDPL SLGVLKSPHE
260 270 280 290 300
YGADVVVGEG QSLGNHMSYG GPHFGFFATK MDYIRYMPGR MAGQTVDVDG
310 320 330 340 350
RVGYVLTLQT REQHIRREKA TSNITSNHWL MALASAVYLS LMGGSLPELG
360 370 380 390 400
QTILNRSTYL AQKLASVGYP LWQRQYFFKE FPIKARDAEA VQEALADSGY
410 420 430
YVGPVIDEHT LLVAVTEKRT KEHMDKLIEL MEGLR
Length:435
Mass (Da):48,463
Last modified:November 25, 2008 - v1
Checksum:i663DD22E41615B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA. Translation: ACI17103.1.
RefSeqiWP_012543755.1. NC_011295.1.
YP_002247381.1. NC_011295.1.

Genome annotation databases

EnsemblBacteriaiACI17103; ACI17103; COPRO5265_1070.
KEGGicpo:COPRO5265_1070.
PATRICi21474958. VBICopPro72829_0989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA. Translation: ACI17103.1.
RefSeqiWP_012543755.1. NC_011295.1.
YP_002247381.1. NC_011295.1.

3D structure databases

ProteinModelPortaliB5Y9D4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309798.COPRO5265_1070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI17103; ACI17103; COPRO5265_1070.
KEGGicpo:COPRO5265_1070.
PATRICi21474958. VBICopPro72829_0989.

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSMYDGST.
OrthoDBiEOG6XWV3B.

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-1061-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35245 / DSM 5265 / BT.

Entry informationi

Entry nameiGCSPA_COPPD
AccessioniPrimary (citable) accession number: B5Y9D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: May 27, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.