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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciCPRO309798:G1GCO-1022-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:COPRO5265_1070
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
Proteomesi
  • UP000001732 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479811 – 435Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST435

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi309798.COPRO5265_1070

Structurei

3D structure databases

ProteinModelPortaliB5Y9D4
SMRiB5Y9D4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B5Y9D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYVPHTKEE IKAMLEAVGL RNVDELFSDI PTEALLKRHL QVEGGWDEEQ
60 70 80 90 100
LRAYFRKAAS SIPDANSAVY FLGGGVYDHY VPSAVDKIIA LPEFYTAYTP
110 120 130 140 150
YQAEISQGTL QAMFEYQSLI CELTGMEVAN GSLYDGASAV AEAVLMAMRI
160 170 180 190 200
NGKRRVLVSE CVHPDIIEVL RTYQLGQDFE ILTLPQKEGV TDLSELEDLS
210 220 230 240 250
NVSCLVMQNP NYYGFLENMN QASELIHKAG GLFVAAVDPL SLGVLKSPHE
260 270 280 290 300
YGADVVVGEG QSLGNHMSYG GPHFGFFATK MDYIRYMPGR MAGQTVDVDG
310 320 330 340 350
RVGYVLTLQT REQHIRREKA TSNITSNHWL MALASAVYLS LMGGSLPELG
360 370 380 390 400
QTILNRSTYL AQKLASVGYP LWQRQYFFKE FPIKARDAEA VQEALADSGY
410 420 430
YVGPVIDEHT LLVAVTEKRT KEHMDKLIEL MEGLR
Length:435
Mass (Da):48,463
Last modified:November 25, 2008 - v1
Checksum:i663DD22E41615B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA Translation: ACI17103.1
RefSeqiWP_012543755.1, NC_011295.1

Genome annotation databases

EnsemblBacteriaiACI17103; ACI17103; COPRO5265_1070
KEGGicpo:COPRO5265_1070

Entry informationi

Entry nameiGCSPA_COPPD
AccessioniPrimary (citable) accession number: B5Y9D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health