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B5Y9D4 (GCSPA_COPPD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:COPRO5265_1070
OrganismCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT) [Complete proteome] [HAMAP]
Taxonomic identifier309798 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147981

Sequences

Sequence LengthMass (Da)Tools
B5Y9D4 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 663DD22E41615B15

FASTA43548,463
        10         20         30         40         50         60 
MRYVPHTKEE IKAMLEAVGL RNVDELFSDI PTEALLKRHL QVEGGWDEEQ LRAYFRKAAS 

        70         80         90        100        110        120 
SIPDANSAVY FLGGGVYDHY VPSAVDKIIA LPEFYTAYTP YQAEISQGTL QAMFEYQSLI 

       130        140        150        160        170        180 
CELTGMEVAN GSLYDGASAV AEAVLMAMRI NGKRRVLVSE CVHPDIIEVL RTYQLGQDFE 

       190        200        210        220        230        240 
ILTLPQKEGV TDLSELEDLS NVSCLVMQNP NYYGFLENMN QASELIHKAG GLFVAAVDPL 

       250        260        270        280        290        300 
SLGVLKSPHE YGADVVVGEG QSLGNHMSYG GPHFGFFATK MDYIRYMPGR MAGQTVDVDG 

       310        320        330        340        350        360 
RVGYVLTLQT REQHIRREKA TSNITSNHWL MALASAVYLS LMGGSLPELG QTILNRSTYL 

       370        380        390        400        410        420 
AQKLASVGYP LWQRQYFFKE FPIKARDAEA VQEALADSGY YVGPVIDEHT LLVAVTEKRT 

       430 
KEHMDKLIEL MEGLR 

« Hide

References

[1]"The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35245 / DSM 5265 / BT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001145 Genomic DNA. Translation: ACI17103.1.
RefSeqYP_002247381.1. NC_011295.1.

3D structure databases

ProteinModelPortalB5Y9D4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309798.COPRO5265_1070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI17103; ACI17103; COPRO5265_1070.
GeneID6943842.
KEGGcpo:COPRO5265_1070.
PATRIC21474958. VBICopPro72829_0989.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycCPRO309798:GH7M-1061-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_COPPD
AccessionPrimary (citable) accession number: B5Y9D4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families